ArticleThe American journal of tropical medicine and hygiene2007
Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in African children.
Article in The American journal of tropical medicine and hygiene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Predictive factors of plasma HIV suppression during pregnancy: a prospective cohort study in Benin.PloS one · 2013Trial
- Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.PLoS pathogens · 2012Trial
- Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Review
- Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023Review
- Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.Immunological reviews · 2020Review
- A simple protocol for platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes in a resource poor setting.Journal of visualized experiments : JoVE · 2013Article
- Article
- Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.PloS one · 2011Article
- Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria.PloS one · 2011Article
- Strain variation in early innate cytokine induction by Plasmodium falciparum.Parasite immunology · 2010Article
- The role of platelets in the pathogenesis of cerebral malaria.Cellular and molecular life sciences : CMLS · 2010Review
- High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children.The American journal of tropical medicine and hygiene · 2009Article
- Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications.Expert reviews in molecular medicine · 2009Review
- An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype.Infection and immunity · 2008Article
- Experimental conditions affect the outcome of Plasmodium falciparum platelet-mediated clumping assays.Malaria journal · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is an adhesive phenotype commonly found in field isolates that has previously been associated with severe malaria. Here, clumping was assessed in 131 isolates from Malian children. The clumping phenotype was seen in 6% (N = 51) of uncomplicated malaria, 24% (N = 51) of severe malaria, and 45% (N = 29) of high parasitemia non-severe malaria isolates. Multivariate analysis indicated that clumping was strongly positively associated with parasitemia (F(1,122) = 24.1, P < 0.001) but not with disease category (F(2,122) = 1.8, P = 0.17). Therefore platelet-mediated clumping in Malian P. falciparum isolates is primarily associated with high parasitemia and not with severe clinical manifestations of malaria.
Indexed as
Identifiers
17984358PMC2696181W2123655512What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.