ArticleMolecular and cellular biology2008
GATA-1 modulates the chromatin structure and activity of the chicken alpha-globin 3' enhancer.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- CTCF delimits a DNA methylation transition at the intergenic region between the embryonic and adult α-globin genes.Epigenetics · 2026Article
- HP1β and H3K9me3 Regulate Olfactory Receptor Choice and Transcriptional Identity.International journal of molecular sciences · 2026Article
- PRC1-Mediated H2Aub Loop Formation and Function in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Chromatin remodeling effects on enhancer activity.Cellular and molecular life sciences : CMLS · 2016Review
- Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation.Biotechnology and bioengineering · 2014Article
- A long non-coding RNA promotes full activation of adult gene expression in the chicken α-globin domain.Epigenetics · 2014Article
- CTCF demarcates chicken embryonic α-globin gene autonomous silencing and contributes to adult stage-specific gene expression.Epigenetics · 2013Article
- XNP/dATRX interacts with DREF in the chromatin to regulate gene expression.Nucleic acids research · 2012Article
- Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.Nature structural & molecular biology · 2011Article
- Epigenetic regulation of the human p53 gene promoter by the CTCF transcription factor in transformed cell lines.Oncogene · 2010Article
- Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture.Experimental hematology · 2009Article
- Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression.Nucleic acids research · 2009Article
- Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.Genome research · 2009Article
- Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming.Leukemia · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-distance regulatory elements and local chromatin structure are critical for proper regulation of gene expression. Here we characterize the chromatin conformation of the chicken alpha-globin silencer-enhancer elements located 3' of the domain. We found a characteristic and erythrocyte-specific structure between the previously defined silencer and the enhancer, defined by two nuclease hypersensitive sites, which appear when the enhancer is active during erythroid differentiation. Fine mapping of these sites demonstrates the absence of a positioned nucleosome and the association of GATA-1. Functional analyses of episomal vectors, as well as stably integrated constructs, revealed that GATA-1 plays a major role in defining both the chromatin structure and the enhancer activity. We detected a progressive enrichment of histone acetylation on critical enhancer nuclear factor binding sites, in correlation with the formation of an apparent nucleosome-free region. On the basis of these results, we propose that the local chromatin structure of the chicken alpha-globin enhancer plays a central role in its capacity to differentially regulate alpha-globin gene expression during erythroid differentiation and development.
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