ArticleInfection and immunity2008
Pneumocystis carinii exhibits a conserved meiotic control pathway.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Retracing the evolution ofMicrobiology and molecular biology reviews : MMBR · 2024Review
- Pneumocystis Mating-Type Locus and Sexual Cycle during Infection.Microbiology and molecular biology reviews : MMBR · 2021Review
- Is sex necessary for the proliferation and transmission of Pneumocystis?PLoS pathogens · 2018Review
- A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.Clinical microbiology reviews · 2018Review
- Characterization of N-Acetylglucosamine Biosynthesis in Pneumocystis species. A New Potential Target for Therapy.American journal of respiratory cell and molecular biology · 2017Article
- Evidence for a Pneumocystis carinii Flo8-like transcription factor: insights into organism adhesion.Medical microbiology and immunology · 2016Article
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- Pneumocystis.Cold Spring Harbor perspectives in medicine · 2014Review
- The Pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence.The Journal of biological chemistry · 2013Article
- Substrate analysis of the Pneumocystis carinii protein kinases PcCbk1 and PcSte20 using yeast proteome microarrays provides a novel method for Pneumocystis signalling biology.Yeast (Chichester, England) · 2011Article
- Pneumocystis carinii expresses an active Rtt109 histone acetyltransferase.American journal of respiratory cell and molecular biology · 2011Article
- Update on the diagnosis and treatment of Pneumocystis pneumonia.Therapeutic advances in respiratory disease · 2011Review
- Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Characterization of the meiosis-specific recombinase Dmc1 of pneumocystis.The Journal of infectious diseases · 2010Article
- Characterization of PCEng2, a {beta}-1,3-endoglucanase homolog in Pneumocystis carinii with activity in cell wall regulation.American journal of respiratory cell and molecular biology · 2010Article
- The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity.American journal of respiratory cell and molecular biology · 2009Article
- Characterization of a novel ADAM protease expressed by Pneumocystis carinii.Infection and immunity · 2009Article
- Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study.BMC infectious diseases · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pneumocystis carinii is an opportunistic fungus causing severe pneumonia in immune-compromised hosts. Recent evidence suggests that Pneumocystis exists as separate sex types, though definitive evidence is currently lacking. These studies were undertaken to determine whether Pneumocystis maintains functional meiotic control molecules, which are required for sexual life stages in eukaryotes. Using the Pneumocystis carinii Genome Project database, two partial sequences for meiotic control molecules were detected, namely, PCRan1, a presumptive meiotic control kinase, and PCMei2, a homologue to a primary activator of meiosis in Schizosaccharomyces pombe. Rapid amplification of cDNA ends was employed to obtain the full open reading frames and to further investigate the functions of these proteins. These presumptive meiotic control molecules were most homologous to molecules present in S. pombe (52% identical and 67% homologous for PCRan1 and 75% identical and 88% homologous for PCMei2 by BLAST analysis). Heterologous expression of these Pneumocystis meiotic genes in corresponding temperature-sensitive and knockout strains of S. pombe, respectively, further verified the functions of the PCRan1 and PCMei2 proteins. These proteins were further shown to control downstream components of the meiotic pathway in S. pombe. Lastly, in vitro kinase assays were used to determine that PCRan1p phosphorylates PCMei2p. These experiments represent the first characterization of any proteins in P. carinii involved in meiosis and indicate the presence of a conserved meiotic pathway in Pneumocystis. Elucidation of this pathway will be essential in gaining a greater understanding of this important opportunistic fungal pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.