ArticleInfection and immunity2008
Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Protective efficacy of mutant strains ofInfection and immunity · 2026Article
- A lipid-binding protein in black-legged tick saliva selectively recognizesbioRxiv : the preprint server for biology · 2026Article
- Probing the Role ofInfection and immunity · 2021Article
- Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease.PLoS pathogens · 2021Article
- TheFrontiers in microbiology · 2021Article
- Gene Regulation and Transcriptomics.Current issues in molecular biology · 2021Article
- Borrelia burgdorferi spatiotemporal regulation of transcriptional regulator bosR and decorin binding protein during murine infection.Scientific reports · 2020Article
- Short-Chain Fatty Acids Alter Metabolic and Virulence Attributes of Borrelia burgdorferi.Infection and immunity · 2018Article
- Borrelia Host Adaptation Protein (BadP) Is Required for the Colonization of a Mammalian Host by the Agent of Lyme Disease.Infection and immunity · 2018Article
- Spermine and Spermidine Alter Gene Expression and Antigenic Profile of Borrelia burgdorferi.Infection and immunity · 2017Article
- Seroprevalence of Borrelia burgdorferi antibodies in white-tailed deer from Texas.International journal for parasitology. Parasites and wildlife · 2016Article
- Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease.Microbes and infection · 2016Article
- Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi.Infection and immunity · 2015Article
- BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi.Infection and immunity · 2015Article
- Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi.PloS one · 2015Article
- BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection.Infection and immunity · 2014Article
- Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.Infection and immunity · 2014Article
- Transposon mutagenesis as an approach to improved understanding of Borrelia pathogenesis and biology.Frontiers in cellular and infection microbiology · 2014Review
- Immunization with a Borrelia burgdorferi BB0172-derived peptide protects mice against lyme disease.PloS one · 2014Article
- Contributions of environmental signals and conserved residues to the functions of carbon storage regulator A of Borrelia burgdorferi.Infection and immunity · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Borrelia burgdorferi, the causative agent of Lyme disease, undergoes rapid adaptive gene expression in response to environmental signals encountered during different stages of its life cycle in the arthropod vector or the mammalian host. Among all the plasmid-encoded genes of B. burgdorferi, several linear plasmid 54 (lp54)-encoded open reading frames (ORFs) exhibit the greatest differential expression in response to mammalian host-specific temperature, pH, and other uncharacterized signals. These ORFs include members of the paralogous gene family 54 (pgf 54), such as BBA64, BBA65, and BBA66, present on lp54. In an attempt to correlate transcriptional up-regulation of these pgf 54 members to their role in infectivity, we inactivated BBA64 and characterized the phenotype of this mutant both in vitro and in vivo. There were no major differences in the protein profiles between the BBA64 mutant and the control strains, while immunoblot analysis indicated that inactivation of BBA64 resulted in increased levels of BBA65. Moreover, there was no significant difference in the ability of the BBA64 mutant to infect C3H/HeN mice compared to that of its parental or complemented control strains as determined by culturing of viable spirochetes from infected tissues. However, enumeration of spirochetes using quantitative real-time PCR revealed tissue-specific differences, suggesting a minimal role for BBA64 in the survival of B. burgdorferi in select tissues. Infectivity analysis of the BBA64 mutant suggests that B. burgdorferi may utilize multiple determinants to establish infection in mammalian hosts.
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