ArticleProceedings of the National Academy of Sciences of the United States of America2007
Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
- MAPkinases regulate secondary metabolism, sexual development and light dependent cellulase regulation in Trichoderma reesei.Scientific reports · 2023Article
- Review: therapeutic approaches for circadian modulation of the glioma microenvironment.Frontiers in oncology · 2023Review
- Influence of Different Light Regimes on the Mycoparasitic Activity and 6-Pentyl-α-pyrone Biosynthesis in Two Strains ofPathogens (Basel, Switzerland) · 2020Article
- Principles of the animal molecular clock learned from Neurospora.The European journal of neuroscience · 2020Review
- The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings.Translational psychiatry · 2019Review
- Article
- Acetylation of BcHpt Lysine 161 RegulatesFrontiers in microbiology · 2019Article
- Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition inFrontiers in microbiology · 2019Article
- Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals.Frontiers in microbiology · 2019Review
- Article
- The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion.G3 (Bethesda, Md.) · 2017Article
- Circadian clock regulation of mRNA translation through eukaryotic elongation factor eEF-2.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Stress tolerance and virulence of insect-pathogenic fungi are determined by environmental conditions during conidial formation.Current genetics · 2015Article
- Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.PLoS genetics · 2014Article
- The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.PLoS genetics · 2014Article
- Regulation of circadian clocks by redox homeostasis.The Journal of biological chemistry · 2013Review
- Disturbances, organisms and ecosystems: a global change perspective.Ecology and evolution · 2013Article
- Article
- Diverse roles for MAPK signaling in circadian clocks.Advances in genetics · 2013Review
- Circadian activation of the mitogen-activated protein kinase MAK-1 facilitates rhythms in clock-controlled genes in Neurospora crassa.Eukaryotic cell · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensitive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.