ArticleVeterinary immunology and immunopathology2008
Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system.
Article in Veterinary immunology and immunopathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Recombinant GI-19 infectious bronchitis virus induction of humoral immunosuppression with reduced HI antibody response following Newcastle disease virus vaccination and bursal cell apoptosis.Veterinary research · 2026Article
- Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.Nature communications · 2026Article
- Infectious bronchitis-virus-like QX strain transmission, pathogenesis, replication, and host miRNA biogenesis pathway hijacking mechanism.Frontiers in cellular and infection microbiology · 2025Article
- Host Immune Response Modulation in Avian Coronavirus Infection: Tracheal Transcriptome Profiling In Vitro and In Vivo.Viruses · 2024Article
- Comparative effects of medium-chain fatty acids or phytobiotics-based feed additives on performance, caecum microbiota, volatile fatty acid production and intestinal morphology of broilers.Veterinary medicine and science · 2023Article
- Global Emergence of Infectious Bronchitis Virus Variants: Evolution, Immunity, and Vaccination Challenges.Transboundary and emerging diseases · 2023Review
- Comparative trachea transcriptome analysis in SPF broiler chickens infected with avian infectious bronchitis and avian influenza viruses.Virus genes · 2022Article
- Evaluation of viral load and transcriptome changes in tracheal tissue of two hybrids of commercial broiler chickens infected with avian infectious bronchitis virus: a comparative study.Archives of virology · 2022Article
- Article
- Route of infectious bronchitis virus vaccination determines the type and magnitude of immune responses in table egg laying hens.Veterinary research · 2021Article
- Infectious Bronchitis Virus (Gammacoronavirus) in Poultry Farming: Vaccination, Immune Response and Measures for Mitigation.Veterinary sciences · 2021Review
- Host Antiviral Responses against Avian Infectious Bronchitis Virus (IBV): Focus on Innate Immunity.Viruses · 2021Review
- The tracheal virome of broiler chickens with respiratory disease complex in Iran: the metagenomics study.Iranian journal of microbiology · 2021Article
- Effect of TLR agonist on infections bronchitis virus replication and cytokine expression in embryonated chicken eggs.Molecular immunology · 2020Article
- Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cells.BMC genomics · 2019Article
- Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines.The Journal of veterinary medical science · 2019Article
- Differential innate immune responses induced by classical and variant infectious bronchitis viruses in specific pathogen free chicks.Developmental and comparative immunology · 2018Article
- Resiquimod enhances mucosal and systemic immunity against avian infectious bronchitis virus vaccine in the chicken.Microbial pathogenesis · 2018Article
- Reference gene selection for gene expression study in shell gland and spleen of laying hens challenged with infectious bronchitis virus.Scientific reports · 2017Article
- Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although mucosal immune responses are critical for protection of hosts from clinical illness and even mortality caused by mucosal pathogens, the molecular mechanism of mucosal immunity, which is independent of systemic immunity, remains elusive. To explore the mechanistic basis of mucosal protective immunity, gene transcriptional profiling in mucosal tissues was evaluated after the primary and secondary immunization of animals with an attenuated avian infectious bronchitis virus (IBV), a prototype of Coronavirus and a well-characterized mucosal pathogen. Results showed that a number of innate immune factors including toll-like receptors (TLRs), retinoic-acid-inducible gene-1 (RIG-1), type I interferons (IFNs), complements, and interleukin-1 beta (IL-1beta) were activated locally after the primary immunization. This was accompanied or immediately followed by a potent Th1 adaptive immunity as evidenced by the activation of T-cell signaling molecules, surface markers, and effector molecules. A strong humoral immune response as supported by the significantly up-regulated immunoglobulin (Ig) gamma chain was observed in the absence of innate, Th1 adaptive immunity, or IgA up-regulation after the secondary immunization, indicating that the local memory response is dominated by IgG. Overall, the results provided the first detailed kinetics on the molecular basis underlying the development of primary and secondary mucosal immunity. The key molecular signatures identified may provide new opportunities for improved prophylactic and therapeutic strategies to combat mucosal infections.
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