ArticleClinical and experimental immunology2008
Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
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- Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging.Pneumonia (Nathan Qld.) · 2018Article
- Pneumococcal Capsular Polysaccharide Immunity in the Elderly.Clinical and vaccine immunology : CVI · 2017Review
- Detection of bacterial-reactive natural IgM antibodies in desert bighorn sheep populations.PloS one · 2017Article
- Vaccination of adults with 23-valent pneumococcal polysaccharide vaccine induces robust antibody responses against pneumococcal serotypes associated with serious clinical outcomes.Human vaccines & immunotherapeutics · 2016Article
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- Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer.Clinical immunology (Orlando, Fla.) · 2015Review
- Ageing of the B-cell repertoire.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
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- Glucose impairs B-1 cell function in diabetes.Clinical and experimental immunology · 2013Article
- 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies.Journal of virology · 2013Article
- Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans.PLoS neglected tropical diseases · 2012Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The molecular and functional characteristics of natural antibody from the preimmune repertoire have not been explored in detail in man. We describe seven human IgM monoclonal antibodies selected on the basis of pneumococcal polysaccharide binding that share both molecular and functional characteristics with natural antibody, suggesting a common B cell lineage origin. Unlike class-switched antibodies, which are serotype-specific, the antibodies were polyreactive and bound all pneumococcal polysaccharide capsular serotypes tested. Some bound endogenous antigens, including blood group antigens and intermediate filament proteins. All the antibodies used unmutated heavy chain V (IGHV) that are expressed at an increased frequency in the elderly and in the preimmune repertoire. The CDR3 was characterized by long length (mean aa 18.4 (+/-4.2) and selective use of IGHD6 (P < 0.001) and IGHJ6 (P < 0.01) family genes. The clones expressing IGHV1-69 and IGHV 3-21 provided significant passive protection against invasive pneumococcal disease in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.