ArticlePLoS pathogens2007
A p21-activated kinase is required for conidial germination in Penicillium marneffei.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Absence of neutrophils impairs the host defense in murine footpad model of chromoblastomycosis.PLoS neglected tropical diseases · 2025Article
- An Overlooked and Underrated Endemic Mycosis-Talaromycosis and the Pathogenic Fungus Talaromyces marneffei.Clinical microbiology reviews · 2023Review
- p21-activated kinase is involved in the sporulation, pathogenicity, and stress response ofFrontiers in microbiology · 2023Article
- Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora.PLoS neglected tropical diseases · 2022Article
- Review
- The novel Dbl homology/BAR domain protein, MsgA, of Talaromyces marneffei regulates yeast morphogenesis during growth inside host cells.Scientific reports · 2021Article
- Sixty Years from Segretain's Description: What Have We Learned and Should Learn About the Basic Mycology of Talaromyces marneffei?Mycopathologia · 2019Article
- Cla4 PAK-like kinase is required for pathogenesis, asexual/sexual development and polarized growth in Bipolaris maydis.Current genetics · 2019Article
- Calcineurin A Is Essential in the Regulation of Asexual Development, Stress Responses and Pathogenesis inFrontiers in microbiology · 2019Article
- Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo.PLoS pathogens · 2018Article
- MADS-Box Transcription FactorFrontiers in microbiology · 2018Article
- Adaptation to macrophage killing byFuture science OA · 2017Review
- Vanillin Promotes the Germination ofFrontiers in microbiology · 2017Article
- Orchestration of Morphogenesis in Filamentous Fungi: Conserved Roles for Ras Signaling Networks.Fungal biology reviews · 2015Article
- Thermally Dimorphic Human Fungal Pathogens--Polyphyletic Pathogens with a Convergent Pathogenicity Trait.Cold Spring Harbor perspectives in medicine · 2014Review
- Unraveling the molecular basis of temperature-dependent genetic regulation in Penicillium marneffei.Eukaryotic cell · 2013Article
- Morphogenetic circuitry regulating growth and development in the dimorphic pathogen Penicillium marneffei.Eukaryotic cell · 2013Article
- Penicillium marneffei actin expression during phase transition, oxidative stress, and macrophage infection.Molecular biology reports · 2011Article
- In vivo yeast cell morphogenesis is regulated by a p21-activated kinase in the human pathogen Penicillium marneffei.PLoS pathogens · 2009Article
- Fungal adaptation to the mammalian host: it is a new world, after all.Current opinion in microbiology · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asexual spores (conidia) are the infectious propagules of many pathogenic fungi, and the capacity to sense the host environment and trigger conidial germination is a key pathogenicity determinant. Germination of conidia requires the de novo establishment of a polarised growth axis and consequent germ tube extension. The molecular mechanisms that control polarisation during germination are poorly understood. In the dimorphic human pathogenic fungus Penicillium marneffei, conidia germinate to produce one of two cell types that have very different fates in response to an environmental cue. At 25 degrees C, conidia germinate to produce the saprophytic cell type, septate, multinucleate hyphae that have the capacity to undergo asexual development. At 37 degrees C, conidia germinate to produce the pathogenic cell type, arthroconidiating hyphae that liberate uninucleate yeast cells. This study shows that the p21-activated kinase pakA is an essential component of the polarity establishment machinery during conidial germination and polarised growth of yeast cells at 37 degrees C but is not required for germination or polarised growth at 25 degrees C. Analysis shows that the heterotrimeric G protein alpha subunit GasC and the CDC42 orthologue CflA lie upstream of PakA for germination at both temperatures, while the Ras orthologue RasA only functions at 25 degrees C. These findings suggest that although some proteins that regulate the establishment of polarised growth in budding yeast are conserved in filamentous fungi, the circuitry and downstream effectors are differentially regulated to give rise to distinct cell types.
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