ArticleBritish journal of pharmacology2008
In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints.
Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials.British journal of clinical pharmacology · 2011Pooled it
- Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint.Frontiers in veterinary science · 2023Article
- Anti-Inflammatory and Analgesic Properties of the Cannabis Terpene Myrcene in Rat Adjuvant Monoarthritis.International journal of molecular sciences · 2022Article
- Impact of ΔBiomedicines · 2022Article
- Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CBPharmacological reports : PR · 2021Review
- Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist.Frontiers in pharmacology · 2021Review
- Article
- Joint problems arising from lack of repair mechanisms: can cannabinoids help?British journal of pharmacology · 2019Review
- On the influence of cannabinoids on cell morphology and motility of glioblastoma cells.PloS one · 2019Article
- Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis.Journal of pain research · 2017Article
- The CBCellular and molecular life sciences : CMLS · 2016Review
- Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation.PloS one · 2016Article
- Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.Arthritis research & therapy · 2014Article
- Cannabinoid receptor 2 protects against acute experimental sepsis in mice.Mediators of inflammation · 2013Article
- Dynamic changes to the endocannabinoid system in models of chronic pain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Neurophysiology of arthritis pain.Current pain and headache reports · 2012Review
- Tissue Engineering of Cartilage; Can Cannabinoids Help?Pharmaceuticals (Basel, Switzerland) · 2010Review
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeCannabinoids (CBs) are known to be vasoactive and to regulate tissue inflammation. The present study examined the in vivo vasomotor effects of the CB2 receptor agonists JWH015 and JWH133 in rat knee joints. The effect of acute and chronic joint inflammation on CB2 receptor-mediated responses was also tested. EXPERIMENTAL APPROACH: Blood flow was assessed in rat knee joints by laser Doppler imaging both before and following topical administration of CB2 receptor agonists. Vasoactivity was measured in normal, acute kaolin/carrageenan inflamed and Freund's complete adjuvant chronically inflamed knees. KEY
resultsIn normal animals, JWH015 and JWH133 caused a concentration-dependent increase in synovial blood flow which in the case of JWH133 was blocked by the selective CB2 receptor antagonist AM630 as well as the transient receptor potential vanilloid-1 (TRPV1) antagonist SB366791. The vasodilator effect of JWH133 was significantly attenuated in both acute and chronically inflamed knees. Given alone, AM630 had no effect on joint blood flow. CONCLUSION AND IMPLICATIONS: In normal joints, the cannabinomimetic JWH133 causes hyperaemia via a CB2 and TRPV1 receptor mechanism. During acute and chronic inflammation, however, this vasodilatatory response is significantly attenuated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.