ArticleNature genetics2007
Rheumatoid arthritis association at 6q23.
Article in Nature genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 15 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
209 citing papers in PubMed, 15 syntheses or guidelines pooled it.
- Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.Oncotarget · 2017Pooled it
- TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis.Oncotarget · 2016Pooled it
- Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.The Journal of investigative dermatology · 2012Pooled it
- A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.European journal of human genetics : EJHG · 2011Pooled it
- Difference between age-related macular degeneration and polypoidal choroidal vasculopathy in the hereditary contribution of the A69S variant of the age-related maculopathy susceptibility 2 gene (ARMS2).Molecular vision · 2011Pooled it
- Association of the CCR5 gene with juvenile idiopathic arthritis.Genes and immunity · 2010Pooled it
- Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples.Annals of the rheumatic diseases · 2010Pooled it
- Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.Annals of the rheumatic diseases · 2010Pooled it
- Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.Rheumatology (Oxford, England) · 2010Pooled it
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.Nature genetics · 2010Pooled it
- Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.Annals of the rheumatic diseases · 2010Pooled it
- Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.Genes and immunity · 2009Pooled it
- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.Arthritis research & therapy · 2009Pooled it
- Common variants at CD40 and other loci confer risk of rheumatoid arthritis.Nature genetics · 2008Pooled it
- Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.Scientific reports · 2016Trial
- The power of genetics in decoding Sjögren's disease: current status and future development.Current opinion in immunology · 2026Review
- Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis.Immunity, inflammation and disease · 2026Article
- Functional dissection of noncoding variants associated with rheumatoid arthritis.Annals of the rheumatic diseases · 2025Article
- An overview on Sjögren's syndrome and systemic lupus erythematosus' genetics.Toxicology research · 2025Review
149 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.