ArticleThe American journal of pathology2007
The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Investigation of serum survivin in dogs suffering from cancer: a multicenter study.Journal of veterinary science · 2021Article
- Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway.Cancer cell international · 2021Article
- Article
- Surface plasmon resonance immunosensor for label-free detection of BIRC5 biomarker in spontaneously occurring canine mammary tumours.Scientific reports · 2019Article
- Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?Journal of transplantation · 2018Review
- Survivin expression pattern in the intestine of normoxic and ischemic rats.BMC gastroenterology · 2017Article
- Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro.International journal of molecular medicine · 2016Article
- Secoisolariciresinol diglucoside in high-fat diet and streptozotocin-induced diabetic nephropathy in rats: a possible renoprotective effect.Journal of physiology and biochemistry · 2014Article
- The role of survivin in podocyte injury induced by puromycin aminonucleoside.International journal of molecular sciences · 2014Article
- Survivin mediates renal proximal tubule recovery from AKI.Journal of the American Society of Nephrology : JASN · 2013Article
- The occupation of intestinal epithelium by Trichinella spiralis in BALB/C mice is not associated with local manifestation of apoptosis related factors.Parasitology research · 2013Article
- [The oncofetal gene survivin - a possible target gene for regenerative therapy concepts in cartilaginous tissue].Der Orthopade · 2012Article
- Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter.International journal of biochemistry and molecular biology · 2012Article
- Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.PloS one · 2012Article
- [Possible molecular mechanisms of spontaneous remission in sudden idiopathic hearing loss].HNO · 2011Review
- The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro.BMC musculoskeletal disorders · 2011Article
- The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro.BMC cancer · 2011Article
- An otoprotective role for the apoptosis inhibitor protein survivin.Cell death & disease · 2010Article
- Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibitor of apoptosis protein survivin is of critical importance for regulation of cellular division and survival. Published data point to a restricted function of survivin in embryonic development and cancer; thus survivin has been broadly proposed as an ideal molecular target for specific anti-cancer therapy. In contrast to this paradigm, we report here broad expression of survivin in adult differentiated tissues, as demonstrated at the mRNA and protein levels. Focusing on the kidney, survivin is strongly expressed in proximal tubuli, particularly at the apical membrane, which can be verified in rat, mouse, and human kidneys. In the latter, survivin expression seems to be even stronger in proximal tubuli than in adjacent cancerous tissue. Primary and immortalized human renal tubular cells also showed high levels of survivin protein expression, and RNA interference resulted in a partial G(2)/M arrest of the cell cycle and increased rate of apoptosis. In conclusion, survivin may be of importance for renal pathophysiology and pathology. The predominant apical expression of survivin may indicate a further, yet unknown, function. Interventional strategies to inhibit survivin's function in malignancy need to be carefully (re)evaluated for renal side effects, as well as for other possible organ dysfunctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.