ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly.Cellular & molecular immunology · 2012Trial
- Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- Aging, cancer, and antitumor immunity.International journal of clinical oncology · 2022Review
- The twilight of immunity: emerging concepts in aging of the immune system.Nature immunology · 2018Review
- Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.Oncogene · 2017Review
- Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Ex vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
- Age-related changes in the retinal pigment epithelium (RPE).PloS one · 2012Article
- Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.Ageing research reviews · 2011Review
- Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.The Journal of clinical investigation · 2010Article
- Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice.PloS one · 2010Article
- Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells.Cellular immunology · 2009Article
- Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.Rejuvenation research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cytoskeletal proteins of the ezrin-radixin-moesin (ERM) family contribute to T cell activation in response to Ag, and also to T cell polarization in response to connective tissue matrix proteins and chemokine gradients. Previous work has shown that T cells from aged mice are defective in their ability to develop molecular linkages between surface macromolecules and the underlying cytoskeletal framework, both for proteins that move to the synapse and those that are excluded from the site of T cell-APC interaction. T cells from aged mice also show defective cytoskeletal rearrangements and lamellipodia formation when placed in contact with slides coated with Abs to the TCR/CD3 complex. In this study, we show that old CD4 T cells differ from young CD4 T cells in several aspects of ERM biochemistry, including ERM phosphorylation and ERM associations with CD44, CD43, and EBP50. In addition, CD4 T cells from aged mice show defects in the Rho GTPase activities known to control ERM function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.