ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.Cell reports · 2022Article
- Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.Biochimica et biophysica acta. Biomembranes · 2017Review
- IL-17 Signaling: The Yin and the Yang.Trends in immunology · 2017Review
- TLR2 elicits IL-17-mediated RANKL expression, IL-17, and OPG production in neutrophils from arthritic mice.Mediators of inflammation · 2014Article
- Role of IL-17 in psoriasis and psoriatic arthritis.Clinical reviews in allergy & immunology · 2013Review
- IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection.Clinical & developmental immunology · 2013Review
- Crystal structures of interleukin 17A and its complex with IL-17 receptor A.Nature communications · 2013Article
- Involvement of corneal epithelial cells in the Th17 response in an in vitro bacterial inflammation model.Molecular vision · 2013Article
- Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL.Immunogenetics · 2011Article
- Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury.Hepatology (Baltimore, Md.) · 2011Article
- Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy.Laboratory investigation; a journal of technical methods and pathology · 2011Article
- IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- [Pathogenesis of parodontitis in rheumatic diseases].Zeitschrift fur Rheumatologie · 2010Review
- IL-17RC: a partner in IL-17 signaling and beyond.Seminars in immunopathology · 2010Review
- Structural basis of receptor sharing by interleukin 17 cytokines.Nature immunology · 2009Article
- Structure and signalling in the IL-17 receptor family.Nature reviews. Immunology · 2009Review
- Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.Immunological reviews · 2008Review
- An overview of IL-17 function and signaling.Cytokine · 2008Review
- Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.Cytokine · 2008Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
IL-17 is the hallmark cytokine of the newly described "Th17" lymphocyte population. The composition, subunit dynamics, and ligand contacts of the IL-17 receptor are poorly defined. We previously demonstrated that the IL-17RA subunit oligomerizes in the membrane without a ligand. In this study, computational modeling identified two fibronectin-III-like (FN) domains in IL-17RA connected by a nonstructured linker, which we predicted to mediate homotypic interactions. In yeast two-hybrid, the membrane-proximal FN domain (FN2), but not the membrane-distal domain (FN1), formed homomeric interactions. The ability of FN2 to drive ligand-independent multimerization was verified by coimmunoprecipitation and fluorescence resonance energy transfer microscopy. Thus, FN2 constitutes a "pre-ligand assembly domain" (PLAD). Further studies indicated that the FN2 linker domain contains the IL-17 binding site, which was never mapped. However, the FN1 domain is also required for high affinity interactions with IL-17. Therefore, although the PLAD is located entirely within FN2, effective ligand binding also involves contributions from the linker and FN1.
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