ArticlePlant physiology2008
Identification and characterization of nucleotide-binding site-leucine-rich repeat genes in the model plant Medicago truncatula.
Article in Plant physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.
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162 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- The Brassicaceae Family Displays Divergent, Shoot-Skewed NLR Resistance Gene Expression.Plant physiology · 2018Pooled it
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- Distinct Evolutionary Constraints Shape TNL and CNL Immune Receptors in Wild and Cultivated Tomato.Biology · 2026Article
- Identification of race-specific QTL and candidate genes for Aphanomyces root rot resistance in alfalfa (Medicago sativa L.).G3 (Bethesda, Md.) · 2026Article
- Identification of the NBS-LRR gene family and AkNBS-LRR43 and 100 functional analysis under biotic stress.Plant cell reports · 2026Article
- NLRSeek: A reannotation-based pipeline for mining missing NLR genes in sequenced genomes.aBIOTECH · 2026Article
- Comparative analysis of PRR receptors and R genes reveals structural and functional divergence between wild, ancestral, and commercial citrus species.BMC genomics · 2026Article
- Pan-NLRome ofFrontiers in plant science · 2026Article
- Whole genome sequencing reveals transcriptional and translational elements potentially regulating biotic and abiotic stress responses in cowpea.Scientific reports · 2025Article
- QTL detection and genomic prediction for resistance to anthracnose in alfalfa (Medicago sativa).The plant genome · 2025Article
- Article
- Phylogenetic, Structural, and Evolutionary Insights into Pepper NBS-LRR Resistance Genes.International journal of molecular sciences · 2025Article
- Deciphering the landscape and evolutionary trajectory of NLR immune receptors in Dioscorea alata.Plant molecular biology · 2024Article
- Genome-wide characterization of nitric oxide-induced NBS-LRR genes from Arabidopsis thaliana and their association in monocots and dicots.BMC plant biology · 2024Article
- Complete genome of the Medicago anthracnose fungus,Microbial genomics · 2024Article
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- Comparative pangenome analyses provide insights into the evolution of Brassica rapa resistance gene analogues (RGAs).Plant biotechnology journal · 2023Article
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- Comparative-genomic analysis reveals dynamic NLR gene loss and gain across Apiaceae species.Frontiers in genetics · 2023Article
- Evolutionary history of two evergreenFrontiers in plant science · 2023Article
102 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleotide-binding site (NBS)-Leucine-rich repeat (LRR) gene family accounts for the largest number of known disease resistance genes, and is one of the largest gene families in plant genomes. We have identified 333 nonredundant NBS-LRRs in the current Medicago truncatula draft genome (Mt1.0), likely representing 400 to 500 NBS-LRRs in the full genome, or roughly 3 times the number present in Arabidopsis (Arabidopsis thaliana). Although many characteristics of the gene family are similar to those described on other plant genomes, several evolutionary features are particularly pronounced in M. truncatula, including a high degree of clustering, evidence of significant numbers of ectopic translocations from clusters to other parts of the genome, a small number of more evolutionarily stable NBS-LRRs, and numerous truncations and fusions leading to novel domain compositions. The gene family clearly has had a large impact on the structure of the genome, both through ectopic translocations (potentially, a means of seeding new NBS-LRR clusters), and through two extraordinarily large superclusters. Chromosome 6 encodes approximately 34% of all TIR-NBS-LRRs, while chromosome 3 encodes approximately 40% of all coiled-coil-NBS-LRRs. Almost all atypical domain combinations are in the TIR-NBS-LRR subfamily, with many occurring within one genomic cluster. This analysis shows the gene family not only is important functionally and agronomically, but also plays a structural role in the genome.
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