ArticleApplied and environmental microbiology2008
Mutations in the lux operon of natural dark mutants in the genus Vibrio.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- A Spontaneous Mutation in tfoX Impairs Bioluminescence in Photobacterium kishitanii ANT-2200.Molecular microbiology · 2026Article
- Generation and validation of a versatile inducible multiplex CRISPRi system to examine bacterial regulation in the Euprymna-Vibrio fischeri symbiosis.Archives of microbiology · 2025Article
- Article
- The quorum-sensing systems of Vibrio campbellii DS40M4 and BB120 are genetically and functionally distinct.Environmental microbiology · 2021Article
- Diversity and evolution of bacterial bioluminescence genes in the global ocean.NAR genomics and bioinformatics · 2020Article
- Mathematical Modeling Approaches for Assessing the Joint Toxicity of Chemical Mixtures Based on Luminescent Bacteria: A Systematic Review.Frontiers in microbiology · 2020Review
- Bacterial Quorum Sensing Stabilizes Cooperation by Optimizing Growth Strategies.Applied and environmental microbiology · 2016Article
- Shedding light on bioluminescence regulation in Vibrio fischeri.Molecular microbiology · 2012Article
- Polyphyly of non-bioluminescent Vibrio fischeri sharing a lux-locus deletion.Environmental microbiology · 2012Article
- Contribution of rapid evolution of the luxR-luxI intergenic region to the diverse bioluminescence outputs of Vibrio fischeri strains isolated from different environments.Applied and environmental microbiology · 2011Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Bacterial bioluminescence can display a wide range of intensities among strains, from very bright to undetectable, and it has been shown previously that there are nonluminous vibrios that possess lux genes. In this paper, we report the isolation and characterization of completely dark natural mutants in the genus Vibrio. Screening of over 600 Vibrio isolates with a luxA gene probe revealed that approximately 5% carried the luxA gene. Bioluminescence assays of the luxA-positive isolates, followed by repetitive extragenic palindromic-PCR fingerprinting, showed three unique genotypes that are completely dark. The dark mutants show a variety of lesions, including an insertion sequence, point mutations, and deletions. Strain BCB451 has an IS10 insertion sequence in luxA, a mutated luxE stop codon, and a truncated luxH. Strain BCB494 has a 396-bp deletion in luxC, and strain BCB440 has a frameshift in luxC. This paper represents the first molecular characterization of natural dark mutants and the first demonstration of incomplete lux operons in natural isolates.
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