ArticleApplied and environmental microbiology2008
Novel mechanism for conditional aerobic growth of the anaerobic bacterium Treponema denticola.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
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- Production of indole and hydrogen sulfide by the oxygen-tolerant mutant strain Clostridium sp. Aeroto-AUH-JLC108 contributes to form a hypoxic microenvironment.Archives of microbiology · 2022Article
- Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial-based therapeutics.Periodontology 2000 · 2021Review
- State of the Art in the Culture of the Human Microbiota: New Interests and Strategies.Clinical microbiology reviews · 2020Review
- Modulation of pathogenic oral biofilms towards health with nisin probiotic.Journal of oral microbiology · 2020Article
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- Passive Filtration, Rapid Scanning Electron Microscopy, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry forJournal of clinical microbiology · 2019Article
- A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dioxygen and nitric oxide scavenging by Treponema denticola flavodiiron protein: a mechanistic paradigm for catalysis.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- Life in a Diverse Oral Community - Strategies for Oxidative Stress Survival.Journal of oral biosciences · 2014Article
- Comparative analysis of oral treponemes associated with periodontal health and disease.BMC infectious diseases · 2013Article
- Molecular signaling mechanisms of the periopathogen, Treponema denticola.Journal of dental research · 2011Review
- Transcriptional profiles of Treponema denticola in response to environmental conditions.PloS one · 2010Article
- Native cellular architecture of Treponema denticola revealed by cryo-electron tomography.Journal of structural biology · 2008Article
- The antioxidant master glutathione and periodontal health.Dental research journalReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Treponema denticola, a periodontal pathogen, has recently been shown to exhibit properties of a facultative anaerobic spirochete, in contrast to its previous recognition as an obligate anaerobic bacterium. In this study, the capacity and possible mechanism of T. denticola survival and growth under aerobic conditions were investigated. Factors detrimental to the growth of T. denticola ATCC 33405, such as oxygen concentration and hydrogen sulfide (H(2)S) levels as well as the enzyme activities of gamma-glutamyltransferase, cysteinylglycinase, and cystalysin associated with the cells were monitored. The results demonstrated that T. denticola grew only at deeper levels of broth (>or=3 ml in a 10-ml tube), high inoculation ratios (>or=20% of culture in medium), and short cultivation times (<or=4 days for one passage) and in media containing L-cysteine or glutathione as the substrate for H(2)S production during aerobic growth. The determination of the factors showed that oxygen levels were always lower (0 to 0.6%) with significantly higher concentrations of H(2)S and higher activities of the three enzymes in all cultures grown aerobically. Further data revealed that H(2)S production from the T. denticola enzymes plus their substrates resulted in removal of dissolved O(2) in the growth cultures in a dose-dependent manner. These results demonstrated that T. denticola was able to generate microanaerobic environments in growth media for its survival and growth under aerobic conditions. Furthermore, the organism can be defined as a true obligate anaerobic spirochete. These findings suggest that spirochetes may play a significant role in maintaining the anaerobic environment at diseased sites in periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.