ArticleNucleic acids research2007
A versatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 76 citations in OpenAlex.
- Highly efficient expression of DNA-peptide conjugates in growth-arrested cells.Nature communications · 2026Article
- IGF1R-targeted delivery of a bridged nucleic acid oligonucleotide-peptide conjugate for microRNA-21 inhibition in triple-negative breast cancer.NAR cancer · 2025Article
- PROTAC Degrader of Estrogen Receptor α Targeting DNA-Binding Domain in Breast Cancer.ACS pharmacology & translational science · 2022Article
- Automated Flow Synthesis of Peptide-PNA Conjugates.ACS central science · 2022Article
- Generation of oligonucleotide conjugatesChemical science · 2022Article
- Chemistry of Peptide-Oligonucleotide Conjugates: A Review.Molecules (Basel, Switzerland) · 2021Review
- Article
- Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids.Journal of visualized experiments : JoVE · 2017Article
- Delivery of therapeutic oligonucleotides with cell penetrating peptides.Advanced drug delivery reviews · 2015Review
- Parallel synthesis and splicing redirection activity of cell-penetrating peptide conjugate libraries of a PNA cargo.Organic & biomolecular chemistry · 2013Article
- An activated triple bond linker enables 'click' attachment of peptides to oligonucleotides on solid support.Nucleic acids research · 2011Article
- Integrin targeted delivery of gene therapeutics.Theranostics · 2011Article
- 1,4-linked 1,2,3-Triazole des-peptidic analogues of PNA (TzNA): Synthesis of TzNA oligomers by "click" reaction on solid phase and stabilization of derived triplexes with DNA.Artificial DNA, PNA & XNA · 2010Article
- Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research.Cancer biotherapy & radiopharmaceuticals · 2009Review
- A solid-phase CuAAC strategy for the synthesis of PNA containing nucleobase surrogates.Artificial DNA, PNA & XNAArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specific 1,3 dipolar Hüisgen cycloaddition reaction known as 'click-reaction' between azide and alkyne groups is employed for the synthesis of peptide-oligonucleotide conjugates. The peptide nucleic acids (PNA)/DNA and peptides may be appended either by azide or alkyne groups. The cycloaddition reaction between the azide and alkyne appended substrates allows the synthesis of the desired conjugates in high purity and yields irrespective of the sequence and functional groups on either of the two substrates. The versatile approach could also be employed to generate the conjugates of peptides with thioacetamido nucleic acid (TANA) analog. The click reaction is catalyzed by Cu (I) in either water or in organic medium. In water, approximately 3-fold excess of the peptide-alkyne/azide drives the reaction to completion in 2 h with no side products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.