Evidence map›Paper›PMID 17981771›Full record

ReviewFrontiers in bioscience : a journal and virtual library2008

Mechanisms of chronic rejection in cardiothoracic transplantation.

Matthew J Weiss, Joren C Madsen, Bruce R Rosengard, James S Allan

Abstract readReview
In one paragraph

Review in Frontiers in bioscience : a journal and virtual library, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Cost of Heart Transplant in Iran: A Multicenter Analysis.International journal of organ transplantation medicine · 2021
    Article
  6. Exosomes expressing the self-antigens myosin and vimentin play an important role in syngeneic cardiac transplant rejection induced by antibodies to cardiac myosin.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
  7. Impact of hyperlipidemia on alloimmunity.Current opinion in organ transplantation · 2017
    Review
  8. Cardiac allograft vasculopathy: a donor or recipient induced pathology?Journal of cardiovascular translational research · 2015
    Review
  9. Article
  10. Article
  11. Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy.Arteriosclerosis, thrombosis, and vascular biology · 2014
    Review
  12. Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production.International journal of clinical and experimental pathology · 2014
    Article
  13. Mechanisms of chronic cardiac allograft rejection.Texas Heart Institute journal · 2013
    Review
  14. Review
  15. Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2010
    Article
  16. Symptomatic gastroesophageal reflux disease after lung transplantation.General thoracic and cardiovascular surgery · 2009
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew J WeissTransplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.
Joren C Madsen
Bruce R Rosengard
James S Allan

Funding

THORACIC ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATESU19AI066705 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2005 to 2009
$6.3M
CARDIAC ALLOGRAFT VASCULOPATHY IN MINIATURE SWINER01HL054211 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROSENGARD, BRUCE R · 1996 to 2008
$3.6M
Cardiac Allograft Vasculopathy in Immunodeficient MiceR01HL071932 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2003 to 2006
$1.5M
Chronic Lung Allograft Rejection in MHC-Defined SwineR01HL067110 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ALLAN, JAMES S. · 2002 to 2005
$1.3M
NHLBI NIH HHS P01HL8646NHLBI NIH HHS R01 HL054211NHLBI NIH HHS R01HL054211NHLBI NIH HHS R01 HL067110NHLBI NIH HHS R01 HL071932NHLBI NIH HHS R01HL071932NHLBI NIH HHS R01HL67110NIAID NIH HHS U19 AI066705NIAID NIH HHS U19AI066705
6 · The paper itself

Abstract

Despite significant improvements in early post-transplantation survival rates, long-term patient and graft survival have remained poor, due in large part to the vexing problem of chronic allograft rejection. Attempts to combat this problem with intensification of immunosuppression have led to concomitant increases in the rates of fatal malignancies and infections. In cardiac transplantation, chronic rejection is manifested primarily by a disease entity known as cardiac allograft vasculopathy, an occlusive narrowing of the coronary vessels. In lung transplantation, chronic rejection is typified by obliterative bronchiolitis, an airflow limiting narrowing of the bronchioles. From an immunologic standpoint, chronic rejection is believed to be the end result of repeated immune and non-immune insults to the graft. This review examines the pathophysiology of heart and lung chronic, with emphasis on both immune and non-immune causes.

Indexed as

Immunity, InnateAutoimmunityBrain DeathBronchiolitis ObliteransCell TransplantationGastroesophageal RefluxHeart TransplantationHLA AntigensHumansImmunosuppressive AgentsLung TransplantationOrgan TransplantationStem CellsTissue and Organ ProcurementHLA AntigensImmunosuppressive Agents

Identifiers

PMID17981771
PMCPMC2867599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.