ArticleActa biomaterialia2008
Effects of extracellular matrix analogues on primary human fibroblast behavior.
Article in Acta biomaterialia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Redefining 3D cell culture: Human methacryloyl platelet lysates hydrogels for reliable, consistent, and ethical applications.Materials today. Bio · 2026Article
- Biopolymers for Liver Tissue Engineering: A Systematic Review.Gels (Basel, Switzerland) · 2025Review
- In vivo study of the immune response to bioengineered spider silk spheres.Scientific reports · 2022Article
- Different approaches for transformation of mesenchymal stem cells into hepatocyte-like cells.Stem cell research & therapy · 2020Review
- Optically Transparent Anionic Nanofibrillar Cellulose Is Cytocompatible with Human Adipose Tissue-Derived Stem Cells and Allows Simple Imaging in 3D.Stem cells international · 2019Article
- A Controlled Antibiotic Release System for the Development of Single-Application Otitis Externa Therapeutics.Gels (Basel, Switzerland) · 2017Article
- Cell-cell interaction between vocal fold fibroblasts and bone marrow mesenchymal stromal cells in three-dimensional hyaluronan hydrogel.Journal of tissue engineering and regenerative medicine · 2016Article
- An Optimized Injectable Hydrogel Scaffold Supports Human Dental Pulp Stem Cell Viability and Spreading.Advances in medicine · 2016Article
- Lamellar liquid crystalline phases for cutaneous delivery of Paclitaxel: impact of the monoglyceride.Pharmaceutical research · 2013Article
- Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.Advanced healthcare materials · 2013Article
- Response of fibroblasts to transforming growth factor-β1 on two-dimensional and in three-dimensional hyaluronan hydrogels.Tissue engineering. Part A · 2012Article
- Biocompatibility of a synthetic extracellular matrix on immortalized vocal fold fibroblasts in 3-D culture.Acta biomaterialia · 2010Article
- Cervical tissue engineering using silk scaffolds and human cervical cells.Tissue engineering. Part A · 2010Article
- Polysaccharide-modified synthetic polymeric biomaterials.Biopolymers · 2010Review
- In vivo comparison of biomimetic approaches for tissue regeneration of the scarred vocal fold.Tissue engineering. Part A · 2009Article
- Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery.Biomaterials · 2008Article
- Use of hyaluronan-derived hydrogels for three-dimensional cell culture and tumor xenografts.Current protocols in cell biology · 2008Article
- Modular extracellular matrices: solutions for the puzzle.Methods (San Diego, Calif.) · 2008Article
- Engineering a clinically-useful matrix for cell therapy.Organogenesis · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
In vitro cell culture is a vital research tool for cell biology, pharmacology, toxicology, protein production, systems biology and drug discovery. Traditional culturing methods on plastic surfaces do not accurately represent the in vivo environment, and a paradigm shift from two-dimensional to three-dimensional (3-D) experimental techniques is underway. To enable this change, a variety of natural, synthetic and semi-synthetic extracellular matrix (ECM) equivalents have been developed to provide an appropriate cellular microenvironment. We describe herein an investigation of the properties of four commercially available ECM equivalents on the growth and proliferation of primary human tracheal scar fibroblast behavior, both in 3-D and pseudo-3-D conditions. We also compare subcutaneous tissue growth of 3-D encapsulated fibroblasts in vivo in two of these materials, Matrigel and Extracel. The latter shows increased cell proliferation and remodeling of the ECM equivalent. The results provide researchers with a rational basis for selection of a given ECM equivalent based on its biological performance in vitro and in vivo, as well as the practicality of the experimental protocols. Biomaterials that use a customizable glycosaminoglycan-based hydrogel appear to offer the most convenient and flexible system for conducting in vitro research that accurately translates to in vivo physiology needed for tissue engineering.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.