Evidence map›Paper›PMID 17979973›Full record

ArticleExperimental dermatology2008

Ectopic mineralization of connective tissue in Abcc6-/- mice: effects of dietary modifications and a phosphate binder--a preliminary study.

Jennifer LaRusso, Qiujie Jiang, Qiaoli Li, Jouni Uitto

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental dermatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions.International journal of molecular sciences · 2021
    Review
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  11. Pseudoxanthoma elasticum, the paradigm of heritable ectopic mineralization disorders - can diet help?Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2011
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer LaRussoDepartment of Dermatology and Cutaneous Biology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Qiujie Jiang
Qiaoli Li
Jouni Uitto
Jefferson Institute · USThomas Jefferson University · US

Funding

BIOCHEMISTRY AND MORPHOLOGY OF CONNECTIVE TISSUESR01AR028450 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI UITTO, JOUNI · 1986 to 2019
$6.5M
Molecular Genetics of Familial Tumoral CalcinosisR01AR052627 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI UITTO, JOUNI · 2005 to 2009
$1.6M
NIAMS NIH HHS R01 AR028450NIAMS NIH HHS R01 AR052627NIAMS NIH HHS R01AR28450NIAMS NIH HHS R01AR52627
6 · The paper itself

Abstract

Pseudoxanthoma elasticum (PXE), a heritable multisystem disorder, is caused by mutations in the ABCC6 gene. We have developed a murine model for PXE by targeted inactivation of the corresponding mouse gene. A feature of this mouse model is ectopic mineralization of connective tissue capsule surrounding the bulb of vibrissae. This study was designed to investigate the effect of dietary sevelamer hydrochloride (Renagel), a phosphate binder, and specific mineral modifications on ectopic mineralization of connective tissue in Abcc6-/- mice. Three groups were fed a specific diet: (i) a standard rodent diet, (ii) a standard rodent diet supplemented with sevelamer hydrochloride, and (iii) a custom experimental diet with specific mineral modifications (high phosphorus, low calcium and low magnesium). The degree of mineralization was determined in hematoxylin-eosin-stained sections using computerized morphometric analysis and by chemical assays to measure the calcium and phosphorus content of the vibrissae. The results indicated increased mineralization in the Abcc6-/- mice fed a standard diet or a diet with mineral modifications as compared with control mice fed a standard diet. However, feeding Abcc6-/- mice with diet supplemented with sevelamer hydrochloride did not improve mineralization, in comparison to mice fed with normal diet. Collectively, these results suggest that the mineralization process in PXE may be exacerbated by changes in mineral intake. The role of dietary minerals, and phosphorus in particular, as well as that of phosphate binders, in ectopic mineralization of PXE, merits further investigation.

Indexed as

Feeding BehaviorAnimalsATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette TransportersCalcinosisCalcium PhosphatesChelating AgentsConnective TissueDisease Models, AnimalImage Processing, Computer-AssistedKidneyMiceMice, KnockoutMicroscopyMineralsMyocardiumAbcc6 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette Transporterscalcium phosphateCalcium PhosphatesChelating AgentsMineralsPolyaminesSevelamer

Identifiers

PMID17979973
PMCPMC3357902
OpenAlexW2030564290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.