ArticleJournal of cellular and molecular medicine
Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: shed vesicles as intermediates.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
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- Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands.International journal of molecular sciences · 2023Article
- Telocytes and Their Structural Relationships With the Sperm Storage Tube and Surrounding Cell Types in the Utero-Vaginal Junction of the Chicken.Frontiers in veterinary science · 2022Article
- Telocytes in the Normal and Pathological Peripheral Nervous System.International journal of molecular sciences · 2020Review
- Identification of Telocytes in the Pancreas of Turtles-A role in Cellular Communication.International journal of molecular sciences · 2020Article
- Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation.Redox biology · 2020Article
- Telocytes as a Novel Structural Component in the Muscle Layers of the Goat Rumen.Cell transplantation · 2019Article
- The Art of Intercellular Wireless Communications: Exosomes in Heart Disease and Therapy.Frontiers in cell and developmental biology · 2019Review
- Review
- Effects of Wenxin Keli on Cardiac Hypertrophy and Arrhythmia via Regulation of the Calcium/Calmodulin Dependent Kinase II Signaling Pathway.BioMed research international · 2017Article
- Telocytes and Their Extracellular Vesicles-Evidence and Hypotheses.International journal of molecular sciences · 2016Review
- Reaching out: junctions between cardiac telocytes and cardiac stem cells in culture.Journal of cellular and molecular medicine · 2016Article
- In vitro morphology, viability and cytokine secretion of uterine telocyte-activated mouse peritoneal macrophages.Journal of cellular and molecular medicine · 2015Article
- Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis.Journal of cellular and molecular medicine · 2015Article
- Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility.Journal of cellular and molecular medicine · 2015Article
- Telocytes and putative stem cells in ageing human heart.Journal of cellular and molecular medicine · 2015Article
- Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.Journal of cellular and molecular medicine · 2014Article
- Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography.Journal of cellular and molecular medicine · 2014Article
- Telocytes in neuromuscular spindles.Journal of cellular and molecular medicine · 2013Article
- Immunohistochemical characterization and functional identification of mammary gland telocytes in the self-assembly of reconstituted breast cancer tissue in vitro.Journal of cellular and molecular medicine · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intercalated discs (ID) are complex junctional units that connect cardiac myocytes mechanically and electrochemically. However, there is limited information concerning the cardiomyocyte interaction with interstitial non-muscle cells. Our previous studies showed that myocardial interstitial Cajal-like cells (ICLC) are located in between cardiomyocytes, blood capillaries and nerve fibres. Typically, ICLC have several very long, moniliform, cytoplasmic processes which establish closed contacts with nerve fibres, as well as each other. We report here ultrastructural evidence concerning the relationships of ICLC processes with ID. The ICLC cytoplasmic prolongations (tens micrometers length) preferentially pass by or stop nearby the ID. Transmission electron microscopy emphasized three distinct connecting features between the tips of ICLC extensions and myocytes at the 'mouth' of ID: free or budding shed vesicles, exocytotic multi-vesicular bodies and direct contacts. In the last case, electron-dense repetitive nanostructures ('pillars') (35-40 nm high and 100-150 nm wide, similar to adhesion molecules) fasten the ICLC to the myocytes. All these features suggest a juxtacrine and/or paracrine intercellular mutual modulation of ICLC and cardiomyocytes in the microenvironment of ID, possibly monitoring the cardiac functions, particularly the electrical activity.
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