ReviewJournal of cellular and molecular medicine
The calcium-sensing receptor and its interacting proteins.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Activation profile of the Atlantic salmon (Salmo salar) calcium-sensing receptor (Casr) by selected L-amino acids.Scientific reports · 2025Article
- Molecular regulation of calcium-sensing receptor (CaSR)-mediated signaling.Chronic diseases and translational medicine · 2024Review
- Charting the importance of filamin A posttranslational modifications.The Biochemical journal · 2024Review
- High Salt Upregulates CaThe Journal of pharmacology and experimental therapeutics · 2022Article
- Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation.Frontiers in physiology · 2022Review
- A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe).Annals of pediatric endocrinology & metabolism · 2021Article
- The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.International journal of molecular sciences · 2018Review
- Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future.Frontiers in physiology · 2016Review
- Recent advances in understanding the extracellular calcium-sensing receptor.F1000Research · 2016Review
- ERK signaling mediates CaSR-promoted axon growth.Neuroscience letters · 2015Article
- Claudin-14 underlies Ca⁺⁺-sensing receptor-mediated Ca⁺⁺ metabolism via NFAT-microRNA-based mechanisms.Journal of the American Society of Nephrology : JASN · 2014Article
- High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor.Molecular cancer · 2014Article
- Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.The Journal of biological chemistry · 2014Article
- Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.Diabetologia · 2013Article
- Nitric-oxide synthase knockout modulates Ca²⁺-sensing receptor expression and signaling in mouse mesenteric arteries.The Journal of pharmacology and experimental therapeutics · 2013Article
- The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.The Journal of physiology · 2012Article
- Sleeping parathyroid tumor: rapid hyperfunction after removal of the dominant tumor.The Journal of clinical endocrinology and metabolism · 2012Article
- Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level.The Journal of biological chemistry · 2012Article
- The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Seven membrane-spanning, or G protein-coupled receptors were originally thought to act through het-erotrimeric G proteins that in turn activate intracellular enzymes or ion channels, creating relatively simple, linear signalling pathways. Although this basic model remains true in that this family does act via a relatively small number of G proteins, these signalling systems are considerably more complex because the receptors interact with or are located near additional proteins that are often unique to a receptor or subset of receptors. These additional proteins give receptors their unique signalling personalities. The extracellular Ca-sensing receptor (CaR) signals via Galpha(i), Galpha(q) and Galpha(12/13), but its effects in vivo demonstrate that the signalling pathways controlled by these subunits are not sufficient to explain all its biologic effects. Additional structural or signalling proteins that interact with the CaR may explain its behaviour more fully. Although the CaR is less well studied in this respect than other receptors, several CaR-interacting proteins such as filamin, a potential scaffolding protein, receptor activity modifying proteins (RAMPs) and potassium channels may contribute to the unique characteristics of the CaR. The CaR also appears to interact with additional proteins common to other G protein-coupled receptors such as arrestins, G protein receptor kinases, protein kinase C, caveolin and proteins in the ubiquitination pathway. These proteins probably represent a few initial members of CaR-based signalling complex. These and other proteins may not all be associated with the CaR in all tissues, but they form the basis for understanding the complete nature of CaR signalling.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.