Evidence map›Paper›PMID 17979848›Full record

ReviewImmunological reviews2007

'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.

Yisong Y Wan, Richard A Flavell

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 2 syntheses or guidelines pooled it, 369 citations in OpenAlex.

  1. Pooled it
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  3. Dietary Intake ofNutrients · 2021
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yisong Y WanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Richard A Flavell
Howard Hughes Medical Institute · USYale University · US

Funding

PATHOGENESIS AND PREVENTION OF AUTOIMMUNE DIABETESR01DK051665 · NIDDK · YALE UNIVERSITY · PI FLAVELL, RICHARD A · 1996 to 2011
$3.2M
Howard Hughes Medical InstituteNIDDK NIH HHS R01 DK051665
6 · The paper itself

Abstract

Transforming growth factor-beta (TGF-beta) and forkhead box p3-expressing T-regulatory (Treg) cells are critical in maintaining self-tolerance and immune homeostasis. The immune suppressive functions of TGF-beta and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles of TGF-beta and Treg cells in shaping the immune system and the inflammatory responses. This review discusses our and other's efforts in understanding the negative (Yin) as well as the positive (Yang) roles for TGF-beta and Treg cells in immune regulation.

Indexed as

ImmunityAnimalsForkhead Transcription FactorsHumansMiceT-Lymphocytes, RegulatoryTransforming Growth Factor betaYin-YangForkhead Transcription FactorsTransforming Growth Factor beta

Identifiers

PMID17979848
PMCPMC2614905
OpenAlexW1975605578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.