ArticleJournal of cellular biochemistry2008
B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.
Article in Journal of cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction.American journal of physiology. Cell physiology · 2023Article
- Adenosine Receptors Profile in Fibromuscular Dysplasia.Biomedicines · 2022Article
- Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- The Adenosinergic System as a Therapeutic Target in the Vasculature: New Ligands and Challenges.Molecules (Basel, Switzerland) · 2017Review
- Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension.Frontiers in pharmacology · 2017Review
- IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- A2 adenosine receptors and vascular pathologies.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling.Experimental hematology · 2011Article
- MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.Journal of cellular physiology · 2011Article
- Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA.The Journal of biological chemistry · 2010Article
- Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury.Experimental hematology · 2009Article
- Mechanisms of induction of adenosine receptor genes and its functional significance.Journal of cellular physiology · 2009Review
- TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4.Biochemical and biophysical research communications · 2008Article
- Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling.The Journal of biological chemistry · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The A(2B) adenosine receptor (A(2B)AR) has been described to control various vascular functions, including inhibition of smooth muscle cell proliferation. Here, we sought to understand the regulation of A(2B)AR gene expression in aortic vascular smooth muscle cells (VSMCs), with a focus on the proliferation phase. Assays with A(2B)AR-beta-gal aortic VSMCs, in which the endogenous A(2B)AR gene promoter drives the expression of prokaryotic beta-galactosidase (beta-gal) instead of the endogenous A(2B)AR gene, show that beta-gal expression is upregulated when the cells are induced to exit from cell cycle arrest. Similarly, the level of A(2B)AR mRNA is upregulated in proliferating primary aortic VSMCs. In search of related mechanisms, it was noted that the A(2B)AR gene promoter contains several putative binding sites for the proliferation-inducing transcription factor, B-Myb. Using a clone of the 5' region upstream of the mouse A(2B)AR gene linked to a reporter gene, B-Myb site deletion mutants were generated. It was determined that B-Myb upregulates the A(2B)AR gene promoter, and specific promoter binding sites were identified as functional. In accordance, B-Myb also elevates endogenous A(2B)AR mRNA and receptor activity, and this activity decreases cell proliferation. Our data are novel in that they show that this proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.