ArticleProteomics2007
Quantitative proteomics of intracellular Porphyromonas gingivalis.
Article in Proteomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 69 citations in OpenAlex.
- Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects.International journal of biological sciences · 2025Review
- Influences of bacterial extracellular vesicles on macrophage immune functions.Frontiers in cellular and infection microbiology · 2024Review
- Dysregulation of Stress-Induced Translational Control byMicroorganisms · 2023Article
- Article
- Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated byFrontiers in cellular and infection microbiology · 2017Article
- Genes Contributing toFrontiers in cellular and infection microbiology · 2017Article
- Comparative gene expression analysis of Porphyromonas gingivalis ATCC 33277 in planktonic and biofilms states.PloS one · 2017Article
- What are We Learning and What Can We Learn from the Human Oral Microbiome Project?Current oral health reports · 2016Article
- Investigation of the Cell Surface Proteome of Human Periodontal Ligament Stem Cells.Stem cells international · 2016Article
- Quantitative proteomic analysis of host--pathogen interactions: a study of Acinetobacter baumannii responses to host airways.BMC genomics · 2015Article
- Gene expression changes in Porphyromonas gingivalis W83 after inoculation in rat oral cavity.BMC microbiology · 2015Article
- Article
- Proteomics of Fusobacterium nucleatum within a model developing oral microbial community.MicrobiologyOpen · 2014Article
- Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis.The ISME journal · 2014Article
- Proteome analysis of coinfection of epithelial cells with Filifactor alocis and Porphyromonas gingivalis shows modulation of pathogen and host regulatory pathways.Infection and immunity · 2014Article
- Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models.Journal of proteome research · 2014Article
- Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.PloS one · 2014Article
- Regulon controlled by the GppX hybrid two component system in Porphyromonas gingivalis.Molecular oral microbiology · 2013Article
- The serine phosphatase SerB of Porphyromonas gingivalis suppresses IL-8 production by dephosphorylation of NF-κB RelA/p65.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Whole-cell quantitative proteomic analyses were conducted to investigate the change from an extracellular to intracellular lifestyle for Porphyromonas gingivalis, a Gram-negative intracellular pathogen associated with periodontal disease. Global protein abundance data for P. gingivalis strain ATCC 33277 internalized for 18 h within human gingival epithelial cells and controls exposed to gingival cell culture medium were obtained at sufficient coverage to provide strong evidence that these changes are profound. A total of 385 proteins were overexpressed in internalized P. gingivalis relative to controls; 240 proteins were shown to be underexpressed. This represented in total about 28% of the protein encoding ORFs annotated for this organism, and slightly less than half of the proteins that were observed experimentally. Production of several proteases, including the classical virulence factors RgpA, RgpB, and Kgp, was decreased. A separate validation study was carried out in which a 16-fold dilution of the P. gingivalis proteome was compared to the undiluted sample in order to assess the quantitative false negative rate (all ratios truly alternative). Truly null (no change) abundance ratios from technical replicates were used to assess the rate of quantitative false positives over the entire proteome. A global comparison between the direction of abundance change observed and previously published bioinformatic gene pair predictions for P. gingivalis will assist with future studies of P. gingivalis gene regulation and operon prediction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.