ArticleHuman brain mapping2008
White matter vascular lesions are related to parietal-to-frontal coupling of EEG rhythms in mild cognitive impairment.
Article in Human brain mapping, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06417034 (Hand Training Device For Cognitive Care), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hand Training Device For Cognitive Care
Who cites it
16 citing papers in PubMed.
- A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms.Frontiers in aging neuroscience · 2023Article
- Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients.Brain structure & function · 2022Article
- Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Review
- Robust EEG Based Biomarkers to Detect Alzheimer's Disease.Brain sciences · 2021Article
- Risk Variants in Three Alzheimer's Disease Genes Show Association with EEG Endophenotypes.Journal of Alzheimer's disease : JAD · 2021Article
- Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals.PloS one · 2019Article
- Cortical Network Topology in Prodromal and Mild Dementia Due to Alzheimer's Disease: Graph Theory Applied to Resting State EEG.Brain topography · 2019Article
- Direction of information flow in large-scale resting-state networks is frequency-dependent.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Classification of Healthy Subjects and Alzheimer's Disease Patients with Dementia from Cortical Sources of Resting State EEG Rhythms: A Study Using Artificial Neural Networks.Frontiers in neuroscience · 2016Article
- Classification of Single Normal and Alzheimer's Disease Individuals from Cortical Sources of Resting State EEG Rhythms.Frontiers in neuroscience · 2016Article
- Altered theta oscillations and aberrant cortical excitatory activity in the 5XFAD model of Alzheimer's disease.Neural plasticity · 2015Article
- Electroencephalogram and Alzheimer's disease: clinical and research approaches.International journal of Alzheimer's disease · 2014Review
- Cortical source multivariate EEG synchronization analysis on amnestic mild cognitive impairment in type 2 diabetes.TheScientificWorldJournal · 2014Article
- Direction of Information Flow in Alzheimer's Disease and MCI Patients.International journal of Alzheimer's disease · 2011Article
- Exploring the neural mechanisms of mild cognitive impairment in elderly patients with coronary artery disease using machine learning and source-localized EEG.Frontiers in neurologyArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Do cerebrovascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI) as a putative preclinical stage of AD? Here we tested the hypothesis that directionality of fronto-parietal functional coupling of electroencephalographic (EEG) rhythms is relatively preserved in amnesic MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold) and 78 amnesic MCI. In the MCI subjects, white-matter vascular load was quantified based on magnetic resonance images (0-30 visual rating scale). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), and beta2 (20-30 Hz). Directionality of fronto-parietal functional coupling of EEG rhythms was estimated by directed transfer function software. As main results, (i) fronto-parietal functional coupling of EEG rhythms was higher in magnitude in the Nold than in the MCI subjects; (ii) more interestingly, that coupling was higher at theta, alpha1, alpha2, and beta1 in MCI V+ (high vascular load; N = 42; MMSE = 26) than in MCI V- group (low vascular load; N = 36; MMSE= 26.7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions.
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