ArticleHistochemistry and cell biology2008
Bone regeneration by BMP-2 enhanced adipose stem cells loading on alginate gel.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method.International journal of molecular sciences · 2021Article
- Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment.Biomedicines · 2021Article
- Activation of cannabinoid receptor 2 enhances osteogenic differentiation of bone marrow derived mesenchymal stem cells.BioMed research international · 2015Article
- The osteoblastic differentiation ability of human dedifferentiated fat cells is higher than that of adipose stem cells from the buccal fat pad.Clinical oral investigations · 2014Article
- An animal model study for bone repair with encapsulated differentiated osteoblasts from adipose-derived stem cells in alginate.Iranian journal of basic medical sciences · 2014Article
- The use of adipose stem cells in cranial facial surgery.Stem cell reviews and reports · 2014Review
- Undifferentiated human adipose-derived stromal/stem cells loaded onto wet-spun starch-polycaprolactone scaffolds enhance bone regeneration: nude mice calvarial defect in vivo study.Journal of biomedical materials research. Part A · 2014Article
- The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose-derived stem cells.Tissue engineering. Part B, Reviews · 2014Review
- Iron administration before stem cell harvest enables MR imaging tracking after transplantation.Radiology · 2013Article
- Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture.Stem cells and development · 2013Article
- Osteogenesis of Adipose-Derived Stem Cells.Bone research · 2013Review
- Dedifferentiated fat cells differentiate into osteoblasts in titanium fiber mesh.Cytotechnology · 2013Article
- Response of a preosteoblastic cell line to cyclic tensile stress conditioning and growth factors for bone tissue engineering.Tissue engineering. Part A · 2012Article
- Gene-modified adult stem cells regenerate vertebral bone defect in a rat model.Molecular pharmaceutics · 2011Article
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipose stem cells (ASCs) have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. In this study, ASCs were harvested from normal Sprague-Dawley (SD) rats and transfected by BMP-2 gene before they were loaded on alginate. The ability of bone regeneration was determined in rat critical-size cranial defects. An 8-mm diameter defect was created in the calvarias of 36 rats; these rats were divided into three groups. In experimental group, the defects were filled with alginate gel combined with BMP-2 transfected ASCs; in negative control group, the defects were filled with alginate gel mixed with normal ASCs; in blank controls, the defects were filled with cell-free alginate gel. Four rats of each group were killed and the cranial defect sites were observed at 4, 8 and 16 weeks after surgery. There was complete repair of cranial defects in experimental group using the alginate gel loading BMP-2 transfected ASC, but only partial repair in negative controls and in the blank control. The engineering approach combining BMP-2 enhanced ASCs with alginate gel can therefore stimulate bone regeneration and repair for the large size bone defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.