Evidence map›Paper›PMID 17978603›Full record

ReviewJournal of clinical hypertension (Greenwich, Conn.)2007

Reducing cardiovascular events in high-risk patients: the challenge of managing hypertension in patients with diabetic renal disease.

Robert D Toto

Abstract readReview
In one paragraph

Review in Journal of clinical hypertension (Greenwich, Conn.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Hypertension and the kidney].Wiener medizinische Wochenschrift (1946) · 2008
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Robert D TotoDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8856, USA. robert.toto@utsouthwestern.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension is more prevalent and more difficult to control and is associated with a higher mortality rate in patients with diabetes than in nondiabetic patients. Elevated blood pressure contributes importantly to the development of albuminuria and progression of renal damage in diabetic nephropathy. Strong evidence indicates that the presence of albuminuria and overt nephropathy in patients with type 1 and type 2 diabetes is associated with a marked increase in the rate of fatal and nonfatal cardiovascular events. Blockade of the renin-angiotensin system in patients with type 2 diabetes with or without chronic kidney disease is associated with a significant reduction in risk for cardiovascular events. Renin-angiotensin system-blocking agents should be considered first-step pharmacologic therapy for hypertension in diabetic patients, with addition of other agents, if needed, to meet the recommended blood pressure goal of <130/80 mm Hg. In most instances, a diuretic is also needed to reduce blood pressure.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersCalcium Channel BlockersComorbidityDiabetes Mellitus, Type 2Diabetic AngiopathiesDiabetic NephropathiesDisease ProgressionDiureticsDrug Therapy, CombinationHumansHypertensionLife StyleMineralocorticoid Receptor AntagonistsPractice Guidelines as TopicRandomized Controlled Trials as TopicAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersCalcium Channel BlockersDiureticsMineralocorticoid Receptor Antagonists

Identifiers

PMID17978603
PMCPMC8109917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.