ArticleJournal of clinical hypertension (Greenwich, Conn.)2007
Venous or arterial endothelium evaluation for early cardiovascular dysfunction in hypertensive patients?
Article in Journal of clinical hypertension (Greenwich, Conn.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Venous endothelial function in cardiovascular disease.Bioscience reports · 2022Article
- Protective effects of luteolin on the venous endothelium.Molecular and cellular biochemistry · 2021Article
- Abnormalities of vascular structure and function in pediatric hypertension.Pediatric nephrology (Berlin, Germany) · 2016Review
- Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Androgenicity and venous endothelial function in post-menopausal women.Journal of endocrinological investigation · 2010Article
- Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects.Clinics (Sao Paulo, Brazil) · 2008Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Veins and arteries have active endothelium, producing vasoactive substances like nitric oxide. The aim of this study was to evaluate whether hypertensive patients exhibit venous endothelial dysfunction and to determine the relationship between endothelial-dependent and endothelial-independent vasodilation responses in venous and arterial systems. Sixteen unmedicated patients with stage I and II hypertension and without other risk factors and 15 matched normotensive volunteers had venous and arterial endothelial function evaluated with the dorsal hand vein technique and brachial artery ultrasonography. Hypertensive patients had a marked reduction of maximum dilation to acetylcholine (54.9% +/- 21.6%) compared with normotensive controls (85.2% +/- 27.0%). The flow-mediated dilation responses were reduced in hypertensive patients compared with controls (6.6% +/- 3.3%vs 12.4% +/- 2.6%, respectively). The responses to nitric oxide were similar in both groups, and the responses with the dorsal hand vein technique and flow-mediated dilation agreed in both groups. Hypertensive patients had an attenuated endothelial dependent response, indicating that endothelial dysfunction is also present in the venous system.
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