ArticleProceedings of the National Academy of Sciences of the United States of America2007
JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- A novel lincRNA identified in buffalo oocytes with protein binding characteristics could hold the key for oocyte competence.Molecular biology reports · 2021Article
- Oocyte related factors impacting on embryo quality: relevance forAnimal reproduction · 2018Article
- Maternal histone acetyltransferase KAT8 is required for porcine preimplantation embryo development.Oncotarget · 2017Article
- CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development.Biology of reproduction · 2016Article
- Article
- Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.Biology of reproduction · 2015Article
- Polymorphism of JY-1 gene is not associated with reproductive traits in goats.Molecular biology reports · 2015Article
- Maternal control of early embryogenesis in mammals.Reproduction, fertility, and development · 2015Review
- Expression of TGFβ superfamily components and other markers of oocyte quality in oocytes selected by brilliant cresyl blue staining: relevance to early embryonic development.Molecular reproduction and development · 2015Article
- Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development.Reproduction (Cambridge, England) · 2015Article
- Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species.BMC developmental biology · 2014Article
- Evidence supporting a functional requirement of SMAD4 for bovine preimplantation embryonic development: a potential link to embryotrophic actions of follistatin.Biology of reproduction · 2014Article
- Embryotropic actions of follistatin: paracrine and autocrine mediators of oocyte competence and embryo developmental progression.Reproduction, fertility, and development · 2013Article
- First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits.Molecular biology reports · 2012Article
- MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis.BMC developmental biology · 2011Article
- Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a.Reproductive biology and endocrinology : RB&E · 2011Article
- A novel functional role for the oocyte-specific transcription factor newborn ovary homeobox (NOBOX) during early embryonic development in cattle.Endocrinology · 2011Article
- Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence.Molecular human reproduction · 2008Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Oocyte-specific gene products play a key role in regulation of fertility in mammals. Here, we describe the discovery, molecular characterization, and function of JY-1, a bovine oocyte-expressed gene shown to regulate both function of ovarian granulosa cells and early embryogenesis in cattle and characteristics of JY-1 loci in other species. The JY-1 gene encodes for a secreted protein with multiple mRNA transcripts containing an identical ORF but differing lengths of 3' UTR. JY-1 mRNA and protein are oocyte-specific and detectable throughout folliculogenesis. Recombinant JY-1 protein regulates function of follicle-stimulating hormone-treated ovarian granulosa cells, resulting in enhanced progesterone synthesis accompanied by reduced cell numbers and estradiol production. JY-1 mRNA of maternal origin is also present in early bovine embryos, temporally regulated during the window from meiotic maturation through embryonic genome activation, and is required for blastocyst development. The JY-1 gene has three exons and is located on bovine chromosome 29. JY-1-like sequences are present on syntenic chromosomes of other vertebrate species, but lack exons 1 and 2, including the protein-coding region, suggestive of species specificity in evolution and function of this oocyte-specific gene.
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