ArticleProceedings of the National Academy of Sciences of the United States of America2007
Statistical evaluation of alternative models of human evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers.
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185 citing papers in PubMed.
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- Population Genomic Scans for Natural Selection and Demography.Annual review of genetics · 2024Review
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- Approximate Bayesian computational methods to estimate the strength of divergent selection in population genomics models.Journal of Computational Mathematics and Data Science · 2024Article
- Astrocytes Drive Divergent Metabolic Gene Expression in Humans and Chimpanzees.Genome biology and evolution · 2024Article
- Inference of Coalescence Times and Variant Ages Using Convolutional Neural Networks.Molecular biology and evolution · 2023Article
- Climatic oscillation promoted diversification of spinous assassin bugs during Pleistocene glaciation.Evolutionary applications · 2023Article
- Population Genetics ofTropical medicine and infectious disease · 2023Article
- Geography vs. past climate: the drivers of population genetic structure of the Himalayan langur.BMC ecology and evolution · 2022Article
- Population genetics reveals divergent lineages and ongoing hybridization in a declining migratory fish species complex.Heredity · 2022Article
- The genetic consequences of captive breeding, environmental change and human exploitation in the endangered peninsular pronghorn.Scientific reports · 2022Article
- Evolutionary history and colonization patterns of the wing dimorphic grasshopper Dichroplus vittatus in two Argentinean biomes.Scientific reports · 2022Article
- Evidence for a force favoring GC over AT at short intronic sites in Drosophila simulans and Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
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- The Early Peopling of the Philippines based on mtDNA.Scientific reports · 2020Article
- Twin introductions by independent invader mussel lineages are both associated with recent admixture with a native congener in Australia.Evolutionary applications · 2020Article
125 more citing papers are in PubMed but not listed here.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An appropriate model of recent human evolution is not only important to understand our own history, but it is necessary to disentangle the effects of demography and selection on genome diversity. Although most genetic data support the view that our species originated recently in Africa, it is still unclear if it completely replaced former members of the Homo genus, or if some interbreeding occurred during its range expansion. Several scenarios of modern human evolution have been proposed on the basis of molecular and paleontological data, but their likelihood has never been statistically assessed. Using DNA data from 50 nuclear loci sequenced in African, Asian and Native American samples, we show here by extensive simulations that a simple African replacement model with exponential growth has a higher probability (78%) as compared with alternative multiregional evolution or assimilation scenarios. A Bayesian analysis of the data under this best supported model points to an origin of our species approximately 141 thousand years ago (Kya), an exit out-of-Africa approximately 51 Kya, and a recent colonization of the Americas approximately 10.5 Kya. We also find that the African replacement model explains not only the shallow ancestry of mtDNA or Y-chromosomes but also the occurrence of deep lineages at some autosomal loci, which has been formerly interpreted as a sign of interbreeding with Homo erectus.
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