ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Steroid hormones act transsynaptically within the forebrain to regulate neuronal phenotype and song stereotypy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 109 citations in OpenAlex.
- Neuron soma size and density measurements in rat striatal regions disaggregated by sex and estrous cycle phase.Brain structure & function · 2025Article
- Androgen signaling in LMAN regulates song stereotypy in male canaries.Hormones and behavior · 2024Article
- Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Expression of oxytocin receptors in the zebra finch brain during vocal development.Developmental neurobiology · 2022Article
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Rapid testosterone-induced growth of the medial preoptic nucleus in male canaries.Physiology & behavior · 2019Article
- Dissociable Effects on Birdsong of Androgen Signaling in Cortex-Like Brain Regions of Canaries.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Aromatase inhibition rapidly affects in a reversible manner distinct features of birdsong.Scientific reports · 2016Article
- Lesions targeted to the anterior forebrain disrupt vocal variability associated with testosterone-induced sensorimotor song development in adult female canaries, Serinus canaria.Developmental neurobiology · 2016Article
- Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit.BMC genomics · 2015Article
- Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs.Integrative and comparative biology · 2015Review
- The dual action of estrogen hypothesis.Trends in neurosciences · 2015Review
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
- Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.Frontiers in neuroendocrinology · 2015Review
- Seasonal plasticity of precise spike timing in the avian auditory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.Genome biology · 2015Article
- Testosterone Mediates Seasonal Growth of the Song Control Nuclei in a Tropical Bird.Brain, behavior and evolution · 2015Article
- Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior.Hormones and behavior · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Steroid sex hormones induce dramatic seasonal changes in reproductive related behaviors and their underlying neural substrates in seasonally breeding vertebrates. For example, in adult white-crowned sparrows, increased Spring photoperiod raises circulating testosterone, causing morphological and electrophysiological changes in song-control nuclei, which modify song behavior for the breeding season. We investigated how photoperiod and steroid hormones induce these changes in morphology, electrophysiology, and behavior. Neurons in a song premotor nucleus, the robust nucleus of the arcopallium (RA), show increased intrinsic spontaneous firing rate and soma size when birds are in breeding condition. Using combinations of systemic and unilateral local intracerebral hormonal manipulations, we show that long-day photoperiod accelerates the effects of systemic testosterone on RA neurons via the estradiol-synthesizing enzyme aromatase (CYP19A1); these changes require inputs from the afferent song control nucleus HVC (used as a proper name) and steroid receptor activation within HVC; local coactivation of androgen and estrogen receptors (ARs and ERs, respectively) within HVC, but not RA, is sufficient to cause neuronal changes in RA; activation of ARs in RA is also permissive. Using bilateral local intracerebral hormone-receptor blockade, we found that ARs and ERs in the song-control nucleus HVC mediate systemic testosterone-induced changes in song stereotypy but not rate. This novel transsynaptic effect of gonadal steroids on activity and morphology of RA neurons is part of a concerted change in key premotor nuclei, enabling stereotyped song.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.