ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
In vivo tracing of neural tracts in the intact and injured spinal cord of marmosets by diffusion tensor tractography.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 103 citations in OpenAlex.
- Human induced pluripotent stem cell-derived neural stem/progenitor cell therapy for spinal cord injury: preclinical advances and translational perspectives.Stem cells translational medicine · 2026Review
- SpIC3D imaging for spinal in situ contrast 3D visualization.Cell reports methods · 2025Article
- Microstructural Characteristics of Cervical Spinal Cord Using High Angular Resolution Diffusion Imaging (HARDI) and Tractography in Healthy Subjects.Clinical neuroradiology · 2025Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Clinical application of diffusion tensor tractography to postoperative C5 palsy.Spinal cord series and cases · 2021Article
- Quantitative assessment of cervical spinal cord by diffusion tensor tractography in 3.0 T.La Radiologia medica · 2021Article
- Longitudinal changes in DTI parameters of specific spinal white matter tracts correlate with behavior following spinal cord injury in monkeys.Scientific reports · 2020Article
- Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment.International journal of molecular sciences · 2019Review
- Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds.Frontiers in cellular neuroscience · 2019Review
- Article
- NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Reduced Field of View Diffusion Tensor Imaging and Fiber Tractography of the Pediatric Cervical and Thoracic Spinal Cord Injury.Journal of neurotrauma · 2018Article
- Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution.NeuroImage. Clinical · 2018Article
- Efficacy of Fiber Tractography in the Stereotactic Surgery of the Thalamus for Patients with Essential Tremor.Neurologia medico-chirurgica · 2017Observational
- Diffusion-weighted tractography in the common marmoset monkey at 9.4T.Journal of neurophysiology · 2017Article
- Diffusion tensor imaging and tractography of the sciatic nerve: assessment of fractional anisotropy and apparent diffusion coefficient values relative to the piriformis muscle, a preliminary study.Skeletal radiology · 2017Article
- Recent advances in magnetic resonance neuroimaging of lumbar nerve to clinical applications: A review of clinical studies utilizing Diffusion Tensor Imaging and Diffusion-weighted magnetic resonance neurography.Spine surgery and related research · 2017Review
- Reliability of TMS metrics in patients with chronic incomplete spinal cord injury.Spinal cord · 2016Article
- The crucial role of Erk2 in demyelinating inflammation in the central nervous system.Journal of neuroinflammation · 2016Article
- Longitudinal study on diffusion tensor imaging and diffusion tensor tractography following spinal cord contusion injury in rats.Neuroradiology · 2016Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spinal cord injury, axonal disruption results in motor and sensory function impairment. The evaluation of axonal fibers is essential to assess the severity of injury and efficacy of any treatment protocol, but conventional methods such as tracer injection in brain parenchyma are highly invasive and require histological evaluation, precluding clinical applications. Previous advances in magnetic resonance imaging technology have led to the development of diffusion tensor tractography (DTT) as a potential modality to perform in vivo tracing of axonal fibers. The properties and clinical applications of DTT in the brain have been reported, but technical difficulties have limited DTT studies of the spinal cord. In this study, we report the effective use of DTT to visualize both intact and surgically disrupted spinal long tracts in adult common marmosets. To verify the feasibility of spinal cord DTT, we first performed DTT of postmortem marmosets. DTT clearly illustrated spinal projections such as the corticospinal tract and afferent fibers in control animals, and depicted the severed long tracts in the injured animals. Histology of the spinal cords in both control and injured groups were consistent with DTT findings, verifying the accuracy of DTT. We also conducted DTT in live marmosets and demonstrated that DTT can be performed in live animals to reveal in vivo nerve fiber tracing images, providing an essential tool to evaluate axonal conditions in the injured spinal cord. Taken together, these findings demonstrate the feasibility of applying DTT to preclinical and clinical studies of spinal cord injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.