ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Processing of odor mixtures in the Drosophila antennal lobe reveals both global inhibition and glomerulus-specific interactions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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120 citing papers in PubMed.
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
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- Neuron synchronization analyzed through spatial-temporal attention.Frontiers in computational neuroscience · 2025Article
- Peripheral preprocessing inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Shallow networks run deep: Peripheral preprocessing facilitates odor classification.bioRxiv : the preprint server for biology · 2023Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Geosmin suppresses defensive behaviour and elicits unusual neural responses in honey bees.Scientific reports · 2023Article
- Anatomic and neurochemical analysis of the palpal olfactory system in the red flour beetleFrontiers in cellular neuroscience · 2023Article
- Parallel encoding of COCurrent biology : CB · 2022Article
- Biological constraints on configural odour mixture perception.The Journal of experimental biology · 2022Article
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- Hyperbolic odorant mixtures as a basis for more efficient signaling between flowering plants and bees.PloS one · 2022Article
- Metamorphic development of the olfactory system in the red flour beetle (Tribolium castaneum, HERBST).BMC biology · 2021Article
- Social modulation of individual preferences in cockroaches.iScience · 2021Article
- The Olfactory Chemosensation of Hematophagous Hemipteran Insects.Frontiers in physiology · 2021Review
- Olfactory systems across mosquito species.Cell and tissue research · 2021Review
60 more citing papers are in PubMed but not listed here.
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Abstract
To understand how odor information is represented and processed in the antennal lobe (AL) of Drosophila melanogaster, we have optically recorded glomerular calcium responses to single odors and odor mixtures from olfactory sensory neurons (OSNs) and projection neurons (PNs). Odor mixtures offer a good tool to analyze odor processing because experimental results can be tested against clear predictions. At the level of the OSNs, the representation of odor mixtures could be predicted from the response patterns of the components in most cases. PN responses to mixtures, however, provide evidences of interglomerular inhibition. Application of picrotoxin (PTX), an antagonist of GABA(A)-like receptors, enhanced odor responses, modified their temporal course, and eliminated mixture suppression at the PN level. Our results can be best explained by postulating the existence of at least two local networks in the fly AL: a glomerulus specific network, which includes excitatory and inhibitory connections and a PTX sensitive inhibitory global network that acts on all glomeruli with proportional strength to the global AL input.
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