ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Neurobiology of escalated aggression and violence.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 241 citations in OpenAlex.
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- The Healthy Brains and Behavior Study: objectives, design, recruitment, and population coverage.International journal of methods in psychiatric research · 2013Trial
- Chronic tiagabine administration and aggressive responding in individuals with a history of substance abuse and antisocial behavior.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Ventromedial hypothalamus IL-6 signaling mediates the excessive aggressive behavior induced by late-gestational sleep deprivation in male mice.Behavioral and brain functions : BBF · 2026Article
- Repeated Stress Escalates Aggression and Activity in Fronto-Limbic Regions in Cntnap2Genes, brain, and behavior · 2026Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Addressing Combative Behaviour in Spanish Bulls by Measuring Hormonal Indicators.Veterinary sciences · 2024Article
- Serotonin drives aggression and social behaviors of laboratory male mice in a semi-natural environment.Frontiers in behavioral neuroscience · 2024Article
- Exploring the relationships between dominance behavioral system, mentalization, theory of mind and assertiveness: analysis in a non-clinical sample.Frontiers in psychology · 2024Article
- Article
- Anesthetic-loaded nanodroplets with focused ultrasound reduces agitation in Alzheimer's mice.Annals of clinical and translational neurology · 2023Article
- Sex Differences in Social Cognition.Current topics in behavioral neurosciences · 2023Review
- Article
- Habenula as a Neural Substrate for Aggressive Behavior.Frontiers in psychiatry · 2022Review
- URB597 induces subtle changes to aggression in adult Lister Hooded rats.Frontiers in psychiatry · 2022Article
- Sniffing the human body volatile hexadecanal blocks aggression in men but triggers aggression in women.Science advances · 2021Article
- Effects of eliminating interactions in multi-layer culture on survival, food utilization and growth of small sea urchins Strongylocentrotus intermedius at high temperatures.Scientific reports · 2021Article
- Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice.Brain sciences · 2021Article
- Forest Manners Exchange: Forest as a Place to Remedy Risky Behaviour of Adolescents: Mixed Methods Approach.International journal of environmental research and public health · 2021Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 3 countries.
Funding
Abstract
Psychopathological violence in criminals and intense aggression in fruit flies and rodents are studied with novel behavioral, neurobiological, and genetic approaches that characterize the escalation from adaptive aggression to violence. One goal is to delineate the type of aggressive behavior and its escalation with greater precision; second, the prefrontal cortex (PFC) and brainstem structures emerge as pivotal nodes in the limbic circuitry mediating escalated aggressive behavior. The neurochemical and molecular work focuses on the genes that enable invertebrate aggression in males and females and genes that are expressed or suppressed as a result of aggressive experiences in mammals. The fruitless gene, immediate early genes in discrete serotonin neurons, or sex chromosome genes identify sexually differentiated mechanisms for escalated aggression. Male, but not female, fruit flies establish hierarchical relationships in fights and learn from previous fighting experiences. By manipulating either the fruitless or transformer genes in the brains of male or female flies, patterns of aggression can be switched with males using female patterns and vice versa. Work with Sts or Sry genes suggests so far that other genes on the X chromosomes may have a more critical role in female mouse aggression. New data from feral rats point to the regulatory influences on mesocortical serotonin circuits in highly aggressive animals via feedback to autoreceptors and via GABAergic and glutamatergic inputs. Imaging data lead to the hypothesis that antisocial, violent, and psychopathic behavior may in part be attributable to impairments in some of the brain structures (dorsal and ventral PFC, amygdala, and angular gyrus) subserving moral cognition and emotion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.