ArticleJournal of clinical microbiology2008
Prospective identification of enteroviruses involved in meningitis in 2006 through direct genotyping in cerebrospinal fluid.
Article in Journal of clinical microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 96 citations in OpenAlex.
- Differential cytokine signature profiles in neonates, infants, and children with enterovirus meningitis.Journal of virology · 2026Observational
- Evaluation of substances of abuse consumption and enterovirus prevalence in Barcelona's (Spain) urban wastewater and their correlation with socioeconomic variables.Journal of water and health · 2026Article
- A meningoencephalitis outbreak associated with echovirus type 18 (E18) in south-western Hungary in mid-2023.Archives of virology · 2024Article
- Article
- Detection of Enteroviruses and SARS-CoV-2 in Tunisian Wastewater.Food and environmental virology · 2023Article
- Article
- Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide.Virology journal · 2022Article
- Molecular characterization of enterovirus detected in cerebrospinal fluid and wastewater samples in Monastir, Tunisia, 2014-2017.Virology journal · 2022Article
- Molecular epidemiological characteristics of echovirus 6 in mainland China: extensive circulation of genotype F from 2007 to 2018.Archives of virology · 2021Article
- Analysis of enterovirus genotypes in the cerebrospinal fluid of children associated with aseptic meningitis in Liaocheng, China, from 2018 to 2019.BMC infectious diseases · 2021Article
- Review
- Assessment of blood enterovirus PCR testing in paediatric populations with fever without source, sepsis-like disease, or suspected meningitis: a prospective, multicentre, observational cohort study.The Lancet. Infectious diseases · 2018Article
- Echovirus 30 and coxsackievirus A9 infection among young neonates with sepsis in Iran.Iranian journal of microbiology · 2018Article
- Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997-2010.Virology journal · 2018Article
- Article
- Ambulatory Pediatric Surveillance of Hand, Foot and Mouth Disease as Signal of an Outbreak of Coxsackievirus A6 Infections, France, 2014-2015.Emerging infectious diseases · 2016Article
- Article
- Enterovirus Migration Patterns between France and Tunisia.PloS one · 2015Article
- Detection of Enteroviruses in Influent and Effluent Flow Samples from Wastewater Treatment Plants in Italy.Food and environmental virology · 2014Article
- Molecular epidemiology of human enterovirus associated with aseptic meningitis in Shandong Province, China, 2006-2012.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterovirus infections were investigated with special emphasis on performing rapid molecular identification of enterovirus serotypes responsible for aseptic meningitis directly in cerebrospinal fluid (CSF). Enterovirus genotyping was carried out directly with specimens tested for the diagnostic procedure, using two seminested PCR assays designed to amplify the complete and partial gene sequences encoding the VP1 and VP4/VP2 capsid proteins, respectively. The method was used for identifying the enterovirus serotypes involved in meningitis in 45 patients admitted in 2005. Enterovirus genotyping was achieved in 98% of the patients studied, and we obtained evidence of 10 of the most frequent serotypes identified earlier by genotyping of virus isolates. The method was applied for the prospective investigation of 54 patients with meningitis admitted consecutively in 2006. The enterovirus serotypes involved were identified with the cerebrospinal fluid (CSF) of 52 patients (96%) and comprised 13 serotypes within the human enterovirus B species and 1 within the human enterovirus A species. The three most common serotypes were echovirus 13 (E13; 24%), E6 (23%), and coxsackievirus B5 (11.5%), a pattern different from that observed in 2005. Genotyping of virus isolates was also performed in 35 patients in 2006 (meningitis, n = 31; other diseases, n = 4). By comparison, direct genotyping in CSF yielded a more complete pattern of enterovirus serotypes, thereby allowing the detection of rare serotypes: three less common serotypes (CB2, E21, and E27) were not detected by indirect genotyping alone. The study shows the feasibility of prospective enterovirus genotyping within 1 week in a laboratory setting.
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