ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Genetic variation in salt taste receptors impact salt intake and blood pressure.Scientific reports · 2023Article
- Salt Taste and Salt Sensitive Hypertension in HIV.Current hypertension reports · 2023Review
- Osmotic Adaptation by NaBiomedicines · 2020Review
- Is the Amiloride-Sensitive Na+ Channel in Taste Cells Really ENaC?Chemical senses · 2020Review
- Article
- Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.Trends in neurosciences · 2018Review
- Modulation of taste processing by temperature.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- The cellular mechanism for water detection in the mammalian taste system.Nature neuroscience · 2017Article
- Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats.PloS one · 2017Article
- Potential role of gene-environment interactions in ion transport mechanisms in the etiology of renal cell cancer.Scientific reports · 2016Article
- Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.Chemical senses · 2016Article
- Inflammatory stimuli acutely modulate peripheral taste function.Journal of neurophysiology · 2016Article
- Review
- Harvest and primary culture of the murine aldosterone-sensitive distal nephron.American journal of physiology. Renal physiology · 2015Article
- Influence of stimulus and oral adaptation temperature on gustatory responses in central taste-sensitive neurons.Journal of neurophysiology · 2015Article
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- Salty taste acuity is affected by the joint action of αENaC A663T gene polymorphism and available zinc intake in young women.Nutrients · 2013Article
- NaCl taste thresholds in 13 inbred mouse strains.Chemical senses · 2012Article
- ENaCs and ASICs as therapeutic targets.American journal of physiology. Cell physiology · 2012Review
- Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells.American journal of physiology. Cell physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
An epithelial Na(+) channel (ENaC) is expressed in taste cells and may be involved in the salt taste transduction. ENaC activity is blocked by amiloride, which in several mammalian species also inhibits taste responses to NaCl. In mice, lingual application of amiloride inhibits NaCl responses in the chorda tympani (CT) gustatory nerve much stronger in the C57BL/6 (B6) strain than in the 129P3/J (129) strain. We examined whether this strain difference is related to gene sequence variation or mRNA expression of three ENaC subunits (alpha, beta, gamma). Real-time RT-PCR and in situ hybridization detected no significant strain differences in expression of all three ENaC subunits in fungiform papillae. Sequences of the beta- and gammaENaC subunit genes were also similar in the B6 and 129 strains, but alphaENaC gene had three single nucleotide polymorphisms (SNPs). One of these SNPs resulted in a substitution of arginine in the B6 strain to tryptophan in the 129 strain (R616W) in the alphaENaC protein. To examine association of this SNP with amiloride sensitivity of CT responses to NaCl, we produced F(2) hybrids between B6 and 129 strains. Amiloride inhibited CT responses to NaCl in F(2) hybrids with B6/129 and B6/B6 alphaENaC R616W genotypes stronger than in F(2) hybrids with 129/129 genotype. This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.