ArticleAmerican journal of physiology. Renal physiology2008
Effect of thyroid hormone on the postnatal renal expression of NHE8.
Article in American journal of physiology. Renal physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Physiological Function and Potential Role of the Ubiquitous NaInternational journal of molecular sciences · 2022Review
- Thyroid Parameters and Kidney Disorder in Type 2 Diabetes: Results from the METAL Study.Journal of diabetes research · 2020Article
- Assessment of renal function and electrolytes in patients with thyroid dysfunction in Addis Ababa, Ethiopia: a cross sectional study.The Pan African medical journal · 2016Article
- Developmental changes in renal tubular transport-an overview.Pediatric nephrology (Berlin, Germany) · 2015Review
- Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.American journal of physiology. Renal physiology · 2015Article
- Molecular mechanisms and regulation of urinary acidification.Comprehensive Physiology · 2014Review
- Steroids combined with levothyroxine to treat children with idiopathic nephrotic syndrome: a retrospective single-center study.Pediatric nephrology (Berlin, Germany) · 2014Article
- Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4.American journal of physiology. Renal physiology · 2014Article
- Glucocorticoids Reduce Renal NHE8 Expression.Physiological reports · 2013Article
- NHE8 plays important roles in gastric mucosal protection.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice.American journal of physiology. Renal physiology · 2012Article
- Acid increases NHE8 surface expression and activity in NRK cells.American journal of physiology. Renal physiology · 2012Article
- Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.Journal of pediatric gastroenterology and nutrition · 2011Article
- Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4.American journal of physiology. Renal physiology · 2011Article
- Effect of metabolic acidosis on neonatal proximal tubule acidification.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- The regulation of proximal tubular salt transport in hypertension: an update.Current opinion in nephrology and hypertension · 2009Review
- Luminal Na(+)/H (+) exchange in the proximal tubule.Pflugers Archiv : European journal of physiology · 2009Review
- Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Correlation of Thyroid Hormone Profile with Biochemical Markers of Renal Function in Patients with Undialyzed Chronic Kidney Disease.Indian journal of endocrinology and metabolismArticle
- SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.Molecular aspects of medicineReview
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We previously demonstrated that there are developmental changes in proximal tubule Na(+)/H(+) exchanger (NHE) activity. There is a maturational increase in postnatal brush-border membrane (BBM) vesicle NHE3 protein abundance and decrease in NHE8 protein abundance. The purpose of this study was to determine whether thyroid hormone plays a role in the rat renal maturational isoform switch from NHE8 to NHE3 and whether thyroid hormone regulates NHE8. Administration of thyroid hormone to neonatal rats, before the normal postnatal increase in serum thyroid hormone levels at 3 wk of age, resulted in a premature increase in NHE3/beta-actin BBM protein abundance and mRNA abundance. Thyroid hormone also caused a premature decrease in BBM NHE8/beta-actin protein abundance, whereas there was no change in mRNA expression (standardized to 28s). Rats made hypothyroid from birth were studied at 28 days, after the normal maturational increase in thyroid hormone. In these hypothyroid adult rats, the maturational increase in BBM NHE3 protein abundance and NHE3 mRNA expression was prevented. In contrast, the developmental decrease in BBM NHE8 protein abundance was prevented in hypothyroid adults, but mRNA expression was unchanged in hypothyroid rats. To determine whether the effect of thyroid hormone was due to a direct epithelial effect, we studied normal rat kidney cells in culture. We recently showed that this cell line expresses NHE8, but does not express NHE3. Thyroid hormone caused a decrease in surface expression of NHE8, determined by biotinylation, but total cellular abundance remained unchanged. NHE8 activity, measured as the sodium-dependent rate of intracellular pH recovery from an acid load, was less with thyroid treatment than control. In conclusion, thyroid hormone plays a potential role in the developmental isoform change from NHE8 to NHE3 and decreases NHE8 activity.
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