ReviewCritical reviews in oncology/hematology2008
Role of insulin-like growth factor-1R system in colorectal carcinogenesis.
Review in Critical reviews in oncology/hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Bidirectional Interactions Between Immune Regulation and the Insulin-like Growth Factor Axis in Colorectal Cancer.International journal of molecular sciences · 2026Review
- Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia.International journal of molecular sciences · 2023Review
- Molecular Targets in Biliary Carcinogenesis and Implications for Therapy.The oncologist · 2015Review
- ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells.Biomolecules & therapeutics · 2015Article
- Association of insulin-like growth factor-I receptor polymorphism with colorectal cancer development.Molecular biology reports · 2014Article
- Target identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins.Current cancer drug targets · 2014Article
- In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer.Oncology reports · 2014Article
- Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Differential PKA activation and AKAP association determines cell fate in cancer cells.Journal of molecular signaling · 2013Article
- Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.Therapeutic advances in gastroenterology · 2012Article
- Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemporary oncology (Poznan, Poland) · 2012Article
- Insulin-like growth factor: current concepts and new developments in cancer therapy.Recent patents on anti-cancer drug discovery · 2012Review
- Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.The Journal of clinical investigation · 2012Article
- Dual targeting of the insulin-like growth factor and collateral pathways in cancer: combating drug resistance.Cancers · 2011Article
- The colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information.BMC cancer · 2010Article
- Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.Pharmacological research · 2010Review
- The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs).Journal of translational medicine · 2010Article
- The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer.Oncogene · 2010Article
- Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.The Journal of biological chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.