ArticleMicron (Oxford, England : 1993)2008
Investigation of nano-mechanical properties of annulus fibrosus using atomic force microscopy.
Article in Micron (Oxford, England : 1993), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The mechanical properties measurement could be affected by forceps: a technical note on sampling human annulus fibrosus.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Applying the Techniques of Materials Science towards an Understanding of the Process of Canine Intervertebral Disc Degeneration.Animals : an open access journal from MDPI · 2024Article
- Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration.Materials today. Bio · 2023Article
- A mini-review on the emerging role of nanotechnology in revolutionizing orthopedic surgery: challenges and the road ahead.Frontiers in bioengineering and biotechnology · 2023Review
- Changes in stiffness of the extracellular and pericellular matrix in the anulus fibrosus of lumbar intervertebral discs over the course of degeneration.Frontiers in bioengineering and biotechnology · 2022Article
- 3D virtual reconstruction and quantitative assessment of the human intervertebral disc's annulus fibrosus: a DTI tractography study.Scientific reports · 2021Article
- Disordered Mechanical Stress and Tissue Engineering Therapies in Intervertebral Disc Degeneration.Polymers · 2019Review
- Tissue Engineering of the Intervertebral Disc's Annulus Fibrosus: A Scaffold-Based Review Study.Tissue engineering and regenerative medicine · 2017Review
- [Progress and challenges in tissue engineering of intervertebral disc annulus fibrosus].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Review
- Correlation between biomechanical properties of the annulus fibrosus and magnetic resonance imaging (MRI) findings.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2015Article
- Regional variations in the cellular, biochemical, and biomechanical characteristics of rabbit annulus fibrosus.PloS one · 2014Article
- Immunofluorescence-guided atomic force microscopy to measure the micromechanical properties of the pericellular matrix of porcine articular cartilage.Journal of the Royal Society, Interface · 2012Article
- Force scanning: a rapid, high-resolution approach for spatial mechanical property mapping.Nanotechnology · 2011Article
- Detection of cancerous cervical cells using physical adhesion of fluorescent silica particles and centripetal force.The Analyst · 2011Article
- Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy.Biophysical journal · 2010Article
- Mechanical design criteria for intervertebral disc tissue engineering.Journal of biomechanics · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We describe the use of atomic force microscopy (AFM) to investigate the nanomechanical properties of annulus fibrosus (AF)-the outer fibrous layer of an intervertebral disc (IVD) encapsulating the inner jelly-like mass known as the nucleus pulposus (NP). Disk disease, degenerated discs, slipped discs, and herniated discs are common terms often linked to back pain and are caused due to degeneration of IVD. Due to the variations in the structure and biochemical composition of the IVD, studies of macromechanical properties in the motion segment or AF may lack all significant nanomechanical responses or behaviors. Existing studies do not report the micro or nano level of mechanics of IVD components and whether the nanomechanics of this tissue mimic its macromechanical behavior is not known. Our studies used AFM to investigate the regional micromechanical properties of the AF that have been otherwise difficult due to small sample size of the tissue. Five different zones including peripheral and central were tested mechanically as well as biochemically. Qualitative biochemical staining and quantitative values of nanomechanical properties of different zones are compared and discussed in detail. The results of nanomechanical investigations described in this study not only reveal its mimic at macroscopic level, they represent an important step towards establishing a framework for testing and comparing tissue engineered IVD replacements with native tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.