ArticleArchives of biochemistry and biophysics2007
Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.
Article in Archives of biochemistry and biophysics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A deformylase inhibitor expands therapeutic options for Lyme disease.Research square · 2026Article
- Decreasing peptide deformylase activity is a beneficial strategy for increasing formaldehyde resistance inbioRxiv : the preprint server for biology · 2026Article
- CspZ variant-specific interaction with factor H incorporates a metal site to support Lyme borreliae complement evasion.The Journal of biological chemistry · 2025Article
- Large-Scale Sequencing ofGenes · 2022Review
- Metal utilization in genome-reduced bacteria: Do human mycoplasmas rely on iron?Computational and structural biotechnology journal · 2021Review
- Evolutionary adaptations that enable enzymes to tolerate oxidative stress.Free radical biology & medicine · 2019Review
- Antimicrobial action of calprotectin that does not involve metal withholding.Metallomics : integrated biometal science · 2018Article
- Direct production of a genetically-encoded immobilized biodiesel catalyst.Scientific reports · 2018Article
- The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase.Chemical reviews · 2017Review
- How water molecules affect the catalytic activity of hydrolases--a XANES study of the local structures of peptide deformylase.Scientific reports · 2014Article
- Metal limitation and toxicity at the interface between host and pathogen.FEMS microbiology reviews · 2014Review
- Identification of crucial amino acids of bacterial Peptide deformylases affecting enzymatic activity in response to oxidative stress.Journal of bacteriology · 2014Article
- Manganese and zinc regulate virulence determinants in Borrelia burgdorferi.Infection and immunity · 2013Article
- Iron in intracellular infection: to provide or to deprive?Frontiers in cellular and infection microbiology · 2013Review
- Metal-dependent gene regulation in the causative agent of Lyme disease.Frontiers in cellular and infection microbiology · 2013Review
- Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation.Advances in microbial physiology · 2012Review
- Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis.Microbiology (Reading, England) · 2011Article
- Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferi.Molecular microbiology · 2011Article
- Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.Journal of medicinal chemistry · 2010Article
- Structure of the Ni(II) complex of Escherichia coli peptide deformylase and suggestions on deformylase activities depending on different metal(II) centres.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Peptide deformylase (PDF, E.C. 3.5.1.88) catalyzes the removal of N-terminal formyl groups from nascent ribosome-synthesized polypeptides. PDF contains a catalytically essential divalent metal ion, which is tetrahedrally coordinated by three protein ligands (His, His, and Cys) and a water molecule. Previous studies revealed that the metal cofactor is a Fe2+ ion in Escherichia coli and many other bacterial PDFs. In this work, we found that PDFs from two iron-deficient bacteria, Borrelia burgdorferi and Lactobacillus plantarum, are stable and highly active under aerobic conditions. The native B. burgdorferi PDF (BbPDF) was purified 1200-fold and metal analysis revealed that it contains approximately 1.1 Zn2+ ion/polypeptide but no iron. Our studies suggest that PDF utilizes different metal ions in different organisms. These data have important implications in designing PDF inhibitors and should help address some of the unresolved issues regarding PDF structure and catalytic function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.