ReviewJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2007
Currently used nucleic acid amplification tests for the detection of viruses and atypicals in acute respiratory infections.
Review in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- A Review of Respiratory Infection Caused by the Human Metapneumovirus: Occurrence, Epidemiology, Pathogenesis, Public Health Outcomes, and Intervention Strategies.Health science reports · 2026Article
- AI-powered analysis of viral metagenomic sequencing data for rapid outbreak investigation and novel pathogen discovery.Frontiers in microbiology · 2025Review
- Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016-2019): a retrospective study.BMC veterinary research · 2021Article
- COVID-19: why not learn from the past?Frontiers of medicine · 2021Article
- Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia.Journal of virological methods · 2019Article
- Comparison of Luminex xTAG® RVP fast assay and real time RT-PCR for the detection of respiratory viruses in adults with community-acquired pneumonia.Journal of medical virology · 2016Article
- Comparison of serological methods with PCR-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria.Journal of negative results in biomedicine · 2016Article
- PCR testing for paediatric acute respiratory tract infections.Paediatric respiratory reviews · 2015Review
- Emerging technologies for the clinical microbiology laboratory.Clinical microbiology reviews · 2014Review
- Evaluation of a multiplex ligation-dependent probe amplification assay for the detection of respiratory pathogens in oncological patients.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- Evolving gene targets and technology in influenza detection.Molecular diagnosis & therapy · 2013Review
- Evaluation of the ESPLINE® Influenza A & B-N assay for the detection of influenza A and B in nasopharyngeal aspirates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Article
- On-chip analysis of respiratory viruses from nasopharyngeal samples.Biomedical microdevices · 2011Article
- PCR for detection of respiratory viruses: seasonal variations of virus infections.Expert review of anti-infective therapy · 2011Review
- Determination of the relative economic impact of different molecular-based laboratory algorithms for respiratory viral pathogen detection, including Pandemic (H1N1), using a secure web based platform.Virology journal · 2011Article
- Using the full spectral capacity (six channels) of a real-time PCR instrument can simplify diagnostic laboratory screening and typing protocols for pandemic H1N1 influenza.Influenza and other respiratory viruses · 2011Article
- Advances in the diagnosis of respiratory tract infections: role of the Luminex xTAG respiratory viral panel.Annals of the New York Academy of Sciences · 2011Review
- Diagnosis of respiratory syncytial virus infection.The open microbiology journal · 2011Article
- Emerging advances in rapid diagnostics of respiratory infections.Infectious disease clinics of North America · 2010Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the detection of respiratory viruses conventional culture techniques are still considered as the gold standard. However, results are mostly available too late to have an impact on patient management. The latest developments include appropriate DNA- and RNA-based amplification techniques (both NASBA and PCR) for the detection of an extended number of agents responsible for LRTI. Real time amplification, the latest technical progress, produces, within a considerable shorter time, results with a lower risk of false positives. As results can be obtained within the same day, patient management with appropriate therapy or reduction of unnecessary antibiotic therapy in LRTI will be possible. A number of technical aspects of these amplification assays, and their advantages are discussed. The availability and use of these new diagnostic tools in virology has contributed to a better understanding of the role of respiratory viruses in LRTI. The increasing importance of the viral agents, Mycoplasma pneumoniae and Chlamydophila pneumoniae in ARI is illustrated. A great proportion of ARI are caused by viruses, but their relative importance depends on the spectrum of agents covered by the diagnostic techniques and on the populations studied, the geographical location and the season. The discovery of new viruses is ongoing; examples are the hMPV and the increasing number of coronaviruses. Indications for the use of these rapid techniques in different clinical situations are discussed. Depending on the possibilities, the laboratory could optimize its diagnostic strategy by applying a combination of immunofluorescence for the detection of RSV an IFL, and a combination of real-time amplification tests for other respiratory viruses and the atypical agents. When implementing a strategy, a compromise between sensitivity, clinical utility, turn around time and cost will have to be found.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.