ArticleBiochimica et biophysica acta2007
Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- The molecular functions of RIT1 and its contribution to human disease.The Biochemical journal · 2020Review
- PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Cellular and molecular life sciences : CMLS · 2018Review
- RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.PLoS genetics · 2018Article
- Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.PloS one · 2018Article
- Article
- Rit subfamily small GTPases: regulators in neuronal differentiation and survival.Cellular signalling · 2013Review
- Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway.Neuroscience letters · 2012Article
- Rit GTPase signaling promotes immature hippocampal neuronal survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Rho and Ras GTPases in axon growth, guidance, and branching.Cold Spring Harbor perspectives in biology · 2010Review
- Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.Journal of neurochemistry · 2008Article
- Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Rit is a novel member of the Ras superfamily of small GTP-binding proteins that regulates signaling pathways controlling cellular fate determination. Constitutively activated mutants of Rit induce terminal differentiation of pheochromocytoma (PC6) cells resulting in a sympathetic neuron-like phenotype characterized by the development of highly-branched neurites. Rit signaling has been found to activate several downstream pathways including MEK/ERK, p38 MAPK, Ral-specific guanine nucleotide exchange factors (GEFs), and Rit associates with the Par6 cell polarity machinery. In this study, a series of Rit effector loop mutants was generated to test the importance of these cellular targets to Rit-mediated neuronal differentiation. We find that Rit-mediated neuritogenesis is dependent upon MEK/ERK MAP kinase signaling but independent of RalGEF activation. In addition, in vivo binding studies identified a novel mechanism of Par6 interaction, suggesting that the cell polarity machinery may serve to spatially restrict Rit signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.