ArticleGenome biology2007
Determinants of protein function revealed by combinatorial entropy optimization.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.
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Who cites it
186 citing papers in PubMed.
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- In Silico Prediction and Molecular Docking of SNPs in NRP1 Gene Associated with SARS-COV-2.Biochemical genetics · 2024Article
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- A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella.Journal of assisted reproduction and genetics · 2024Article
126 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
We use a new algorithm (combinatorial entropy optimization [CEO]) to identify specificity residues and functional subfamilies in sets of proteins related by evolution. Specificity residues are conserved within a subfamily but differ between subfamilies, and they typically encode functional diversity. We obtain good agreement between predicted specificity residues and experimentally known functional residues in protein interfaces. Such predicted functional determinants are useful for interpreting the functional consequences of mutations in natural evolution and disease.
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