ArticleRespiratory research2007
Continuous monitoring of the bronchial epithelial lining fluid by microdialysis.
Article in Respiratory research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 28 citations in OpenAlex.
- Pulmonary Pharmacokinetics/Pharmacodynamics of Commonly Used Antibiotics in the Treatment of Community-Acquired Pneumonia.European journal of drug metabolism and pharmacokinetics · 2026Review
- Proteomics ofJournal of fungi (Basel, Switzerland) · 2023Article
- Microdialysis Determination of Cefquinome Pharmacokinetics in Murine Thigh From Healthy, Neutropenic, andFrontiers in pharmacology · 2019Article
- Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.Physiological reports · 2017Observational
- Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds.Frontiers in pharmacology · 2016Review
- The emerging role of urease as a general microbial virulence factor.PLoS pathogens · 2014Article
- Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans.mBio · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContents of the epithelial lining fluid (ELF) of the bronchi are of central interest in lung diseases, acute lung injury and pharmacology. The most commonly used technique broncheoalveolar lavage is invasive and may cause lung injury. Microdialysis (MD) is a method for continuous sampling of extracellular molecules in the immediate surroundings of the catheter. Urea is used as an endogenous marker of dilution in samples collected from the ELF. The aim of this study was to evaluate bronchial MD as a continuous monitor of the ELF.
methodsMicrodialysis catheters were introduced into the right main stem bronchus and into the right subclavian artery of five anesthetized and normoventilated pigs. The flowrate was 2 mul/min and the sampling interval was 60 minutes. Lactate and fluorescein-isothiocyanate-dextran 4 kDa (FD-4) infusions were performed to obtain two levels of steady-state concentrations in blood. Accuracy was defined as [bronchial-MD] divided by [arterial-MD] in percent. Data presented as mean +/- 95 percent confidence interval.
resultsThe accuracy of bronchial MD was calculated with and without correction by the arteriobronchial urea gradient. The arteriobronchial lactate gradient was 1.2 +/- 0.1 and FD-4 gradient was 4.0 +/- 1.2. Accuracy of bronchial MD with a continuous lactate infusion was mean 25.5% (range 5.7-59.6%) with a coefficient of variation (CV) of 62.6%. With correction by the arteriobronchial urea gradient accuracy was mean 79.0% (57.3-108.1%) with a CV of 17.0%.
conclusionUrea as a marker of catheter functioning enhances bronchial MD and makes it useful for monitoring substantial changes in the composition of the ELF.
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