ReviewCellular and molecular life sciences : CMLS2008
Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.
Review in Cellular and molecular life sciences : CMLS, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Macrophage Accumulation and Cyst Expansion in Pkd2 , Ift88 , and Double Mutant Mouse Models.Journal of the American Society of Nephrology : JASN · 2025Article
- Calcium signaling in polycystic kidney disease- cell death and survival.Cell calcium · 2023Review
- Polycystin-1 affects cancer cell behaviour and interacts with mTOR and Jak signalling pathways in cancer cell lines.Journal of cellular and molecular medicine · 2019Article
- Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions.Journal of cellular physiology · 2019Review
- Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1.BioMed research international · 2019Article
- On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.Molecules (Basel, Switzerland) · 2017Review
- Human mutations affect the epigenetic/bookmarking function of HNF1B.Nucleic acids research · 2016Article
- Ouabain Enhances ADPKD Cell Apoptosis via the Intrinsic Pathway.Frontiers in physiology · 2016Article
- Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD.Scientific reports · 2015Article
- The exocyst and regulatory GTPases in urinary exosomes.Physiological reports · 2014Article
- Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development.Human genetics · 2014Article
- microRNA biomarkers in cystic diseases.BMB reports · 2013Review
- The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies.Cellular and molecular life sciences : CMLS · 2013Review
- Review
- The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression.PloS one · 2013Article
- Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy Techniques.Journal of biophysics (Hindawi Publishing Corporation : Online) · 2013Article
- The fate of bone marrow-derived cells carrying a Polycystic Kidney Disease mutation in the genetically normal kidney.BMC nephrology · 2012Article
- Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.Clinical and translational science · 2011Review
- Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture.American journal of physiology. Cell physiology · 2011Article
- Naturally occurring osmolytes modulate the nanomechanical properties of polycystic kidney disease domains.The Journal of biological chemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycystic kidney diseases (PKDs) represent a large group of progressive renal disorders characterized by the development of renal cysts leading to end-stage renal disease. Enormous strides have been made in understanding the pathogenesis of PKDs and the development of new therapies. Studies of autosomal dominant and recessive polycystic kidney diseases converge on molecular mechanisms of cystogenesis, including ciliary abnormalities and intracellular calcium dysregulation, ultimately leading to increased proliferation, apoptosis and dedifferentiation. Here we review the pathobiology of PKD, highlighting recent progress in elucidating common molecular pathways of cystogenesis. We discuss available models and challenges for therapeutic discovery as well as summarize the results from preclinical experimental treatments targeting key disease-specific pathways.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.