ArticleJournal of thrombosis and haemostasis : JTH2008
Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition.
Article in Journal of thrombosis and haemostasis : JTH, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Defective fibrin deposition and thrombus stability in BambiJournal of thrombosis and haemostasis : JTH · 2019Article
- Article
- New insights into the biology of tissue factor pathway inhibitor.Journal of thrombosis and haemostasis : JTH · 2015Review
- Biology of tissue factor pathway inhibitor.Blood · 2014Review
- Coagulation in liver toxicity and disease: role of hepatocyte tissue factor.Thrombosis research · 2014Review
- Review
- Cellular expression and biological activities of alternatively spliced forms of tissue factor pathway inhibitor.Current opinion in hematology · 2013Review
- Article
- Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited.Anesthesia and analgesia · 2012Review
- Tissue factor pathway inhibitor: structure-function.Frontiers in bioscience (Landmark edition) · 2012Review
- Article
- Alternatively spliced isoforms of tissue factor pathway inhibitor.Thrombosis research · 2010Review
- Influence of cellular and plasma procoagulant activity on the fibrin network.Thrombosis research · 2010Review
- Testosterone alleviates tumor necrosis factor-alpha-mediated tissue factor pathway inhibitor downregulation via suppression of nuclear factor-kappa B in endothelial cells.Asian journal of andrology · 2009Article
- Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- Tissue factor pathway inhibitor-gamma is an active alternatively spliced form of tissue factor pathway inhibitor present in mice but not in humans.Journal of thrombosis and haemostasis : JTH · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveTissue factor pathway inhibitor (TFPI) and thrombomodulin (TM) are endothelial-associated anticoagulant proteins thought to control hemostasis in specific vascular beds. Here, we have examined the consequences of TFPI deficiency in the presence of a compounding procoagulant state caused by reduced TM function. METHODS AND
resultsTFPI(+/-)/TM(pro/pro) mice are born at less than expected frequency in either TFPI(+/-)/TM(pro/+) or TM(pro/pro) mothers but are born at near the expected frequency in TM(pro/+) mothers. Adult TFPI(+/-)/TM(pro/pro) mice have elevated thrombin-antithrombin complex and increased thrombus volume in an electrical injury model of venous thrombosis. In striking contrast to mice with single deficiency of TFPI or TM, TFPI(+/-)/TM(pro/pro) mice exhibit augmented fibrin deposition not only in the liver, but also in the cerebral microvasculature.
conclusionsTFPI(+/-)/TM(pro/pro) mice exhibit partial intrauterine lethality when carried by mothers with an underlying prothrombotic state, providing the first experimental evidence in an animal model that TFPI-dependent control of hemostasis in the vascular bed of the placenta fulfills a critical role for successful pregnancy outcome. In addition to the placenta, partial TFPI deficiency interacts with decreased TM function in an organ selective manner to produce fibrin deposition in other specific vascular beds, the liver and brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.