Evidence map›Paper›PMID 17973186›Full record

ArticleGlycoconjugate journal2008

First synthesis of two deoxy Lewis(x) pentaosyl glycosphingolipids.

Yun Luo, Chafika Gourmala, Dengxiang Dong, Florent Barbault, Botao Fan, Yongzhou Hu, Yongmin Zhang

Abstract read
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In one paragraph

Article in Glycoconjugate journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Yun LuoZJU-ENS joint laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Chafika Gourmala
Dengxiang Dong
Florent Barbault
Botao Fan
Yongzhou Hu
Yongmin Zhang
Centre National de la Recherche Scientifique · FRÉcole Normale Supérieure · BIInstitut de Chimie Moléculaire de Paris : organique, inorganique et biologiqueInterfaces Traitements Organisation et Dynamique des Systèmes · FRUniversité Paris Cité · FRZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Lewis(x)-Lewis(x) interaction has been increasingly studied, using a variety of techniques including nuclear magnetic resonance spectroscopy, mass spectrometry, vesicle adhesion, atomic force microscopy, and surface plasmon resonance spectroscopy. However, the detailed molecular mechanism of these weak, divalent cation dependent interactions remains unclear, and new models are needed to probe the nature of this phenomenon in term of key roles of the different hydroxyl groups on Lewis(x) trisaccharide determinant involved in the Lewis(x)-Lewis(x) interaction. An interesting solution is to synthesize a series of Lewis(x) pentaosyl glycosphingolipid derivatives in which one of the eight hydroxyl groups of Lewis(x) trisaccharide is replaced by a hydrogen atom, and to test the adhesion induced by interaction of these derivatives, in order to gain insight into the functions played by the hydroxyl groups of the Lewis(x) trisaccharide. This article describes the synthesis of 3d-deoxy and 4d-deoxy Lewis(x) pentaosyl glycosphingolipids, to be used for study of the Lewis(x)-Lewis(x) interaction.

Indexed as

Carbohydrate ConformationCarbohydrate SequenceGlycosphingolipidsLewis X AntigenMolecular Sequence Data(3-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diol(4-deoxyxylohexopyranosyl)-1-4-(1-fucopyranosyl-1-3)-(2-deoxy-2-acetamidoglucopyranosyl)-1-3-galactopyranosyl-1-4-glucopyranosyl-(1-1)-2-octadecanamido-4-octadecene-1,3-diolGlycosphingolipidsLewis X Antigen

Identifiers

PMID17973186
OpenAlexW2024039448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.