Evidence map›Paper›PMID 17973044›Full record

ReviewPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2007

Photodynamic therapy with fullerenes.

Pawel Mroz, George P Tegos, Hariprasad Gali, Tim Wharton, Tadeusz Sarna, Michael R Hamblin

Open access · greenAbstract readReview
In one paragraph

Review in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 290 citations in OpenAlex.

  1. Review of Antimicrobial Properties of Carbon Nanomaterials.International journal of molecular sciences · 2026
    Review
  2. Review
  3. Review
  4. Recent advancements in nanoparticles for cancer treatment.Medical oncology (Northwood, London, England) · 2025
    Review
  5. Review
  6. Article
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  8. Article
  9. Putting a "CPharmaceuticals (Basel, Switzerland) · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. New Generation of Photosensitizers Based on Inorganic Nanomaterials.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Pawel MrozWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
George P Tegos
Hariprasad Gali
Tim Wharton
Tadeusz Sarna
Michael R Hamblin
Harvard University · USLynntech (United States) · USJagiellonian University · PLMassachusetts General Hospital · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Novel Nanostructures for Topical Photodynamic TherapyR44AI068400 · NIAID · LYNNTECH, INC. · PI LALWANI, SANJIV · 2006 to 2008
$1.2M
Novel Nanostructures for Topical Photodynamic TherapyR43CA103268 · NCI · LYNNTECH, INC. · PI WHARTON, J TIM · 2003 to 2004
$395k
NCI NIH HHS R43 CA103268NCI NIH HHS R43CA103268NIAID NIH HHS R01 AI050875NIAID NIH HHS R01AI050875NIAID NIH HHS R01CA/AI838801NIAID NIH HHS R44 AI068400NIAID NIH HHS R44AI68400
6 · The paper itself

Abstract

Fullerenes are a class of closed-cage nanomaterials made exclusively from carbon atoms. A great deal of attention has been focused on developing medical uses of these unique molecules especially when they are derivatized with functional groups to make them soluble and therefore able to interact with biological systems. Due to their extended pi-conjugation they absorb visible light, have a high triplet yield and can generate reactive oxygen species upon illumination, suggesting a possible role of fullerenes in photodynamic therapy. Depending on the functional groups introduced into the molecule, fullerenes can effectively photoinactivate either or both pathogenic microbial cells and malignant cancer cells. The mechanism appears to involve superoxide anion as well as singlet oxygen, and under the right conditions fullerenes may have advantages over clinically applied photosensitizers for mediating photodynamic therapy of certain diseases.

Indexed as

AnimalsDNA BreaksFullerenesHumansMembranesMutationNeoplasmsPhotobiologyPhotochemistryPhotochemotherapyStaphylococcus aureusVirusesFullerenes

Identifiers

PMID17973044
PMCPMC2933422
OpenAlexW2055486408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.