ReviewAdvances in surgery2007
The role of sentinel lymph node biopsy in the management of melanoma.
Review in Advances in surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Sentinel lymph node biopsy for melanoma: American Society of Clinical Oncology and Society of Surgical Oncology joint clinical practice guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Guideline
- [Data and clinical experience of patients undergoing sentinel lymph node biopsy between 2020 and 2025 at the National Institute of Oncology, Hungary].Magyar onkologia · 2026Article
- Recent Advances in the Management of Malignant Melanoma.Current pharmaceutical design · 2026Article
- Optimizing sentinel lymph node detection in melanoma: the value of dual tracer techniques in unpredictable drainage patterns.Journal of surgical case reports · 2025Article
- Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis.Trends in immunology · 2023Review
- The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis.Clinical & experimental metastasis · 2022Review
- Report on fluorescence lifetime imaging using multiphoton laser scanning microscopy targeting sentinel lymph node diagnostics.Journal of biomedical optics · 2020Article
- Enhanced chemosensitization of anoikis-resistant melanoma cells through syndecan-2 upregulation upon anchorage independency.Oncotarget · 2017Article
- Sentinel node biopsy during thoracolaparoscopic esophagectomy for advanced esophageal cancer.World journal of surgical oncology · 2016Article
- Analysis of melanoma recurrence following a negative sentinel lymph node biopsy.Melanoma management · 2015Review
- Progression of cutaneous melanoma: implications for treatment.Clinical & experimental metastasis · 2012Review
- Nanoscale iodized oil emulsion: a useful tracer for pretreatment sentinel node detection using CT lymphography in a normal canine gastric model.Surgical endoscopy · 2012Article
- Enhanced postoperative lymphatic staging of malignant melanoma by endoscopically assisted iliacoinguinal dissection.Langenbeck's archives of surgery · 2012Article
- A novel immunohistochemical staining method allows ultrarapid detection of lymph node micrometastases while conserving antibody.Acta histochemica et cytochemica · 2011Article
- Preoperative imaging of sentinel lymph nodes in gastric cancer using CT lymphography.Yonsei medical journal · 2010Article
- Significance of sentinel lymph node biopsy in malignant melanoma: overview of international data.International journal of clinical oncology · 2009Review
- Article
- Real-time intraoperative detection of melanoma lymph node metastases using recombinant vaccinia virus GLV-1h68 in an immunocompetent animal model.International journal of cancer · 2009Article
- Melanoma biomarkers: current status and vision for the future.Nature clinical practice. Oncology · 2009Review
- A comprehensive overview of radioguided surgery using gamma detection probe technology.World journal of surgical oncology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During the last 2 decades, the development and wide acceptance of SLN biopsy have affected the management of melanoma profoundly. This technique represents a considerable improvement in the ability to evaluate the tumor status of the regional lymph node basin, which is the most important predictor of survival in patients who have melanoma. Histopathologic and molecular assessment of the SLN has enhanced the detection of clinically occult nodal metastases, thereby distinguishing patients who might benefit from immediate lymphadenectomy from those for whom this procedure is unlikely to be helpful. This technique also identifies patients who would be candidates for clinical trials of adjuvant therapy. Centers can offer SLN biopsy without routine CLND once they reach a level of proficiency that usually corresponds to a learning phase of 55 cases. The role of molecular technology in the identification and analysis of the SLN remains to be established. Although molecular evidence of SLN metastasis has been identified in patients who have early-stage melanoma, its clinical relevance cannot be determined until marker selection is improved. The markers presently under study lack sensitivity and specificity. The role of molecular biomarkers can be validated only through large, multicenter, randomized. controlled trials such as the MSLT-II, a trial that will determine the benefit of multimarker RT-PCR assay in SLN specimens. SLN offers a promising future in staging lymph nodes and will improve the management of patients who have melanoma. Although SLN biopsy has become widely accepted as a minimally invasive technique of staging regional lymph nodes, its use in patients who have melanoma continues to be challenged. The future of SLN biopsy holds promise if prospective multicenter trials confirm a survival benefit for SLN biopsy as compared with watch-and-wait observation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.